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Titolo:
TRAF1 is a negative regulator of TNF signaling: Enhanced TNF signaling in TRAF1-deficient mice
Autore:
Tsitsikov, EN; Laouini, D; Dunn, IF; Sannikova, TY; Davidson, L; Alt, FW; Geha, RS;
Indirizzi:
Harvard Univ, Sch Med, Div Immunol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Div Immunol, Boston, MA 02115 USA Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 rd Hughes Med Inst, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA
Titolo Testata:
IMMUNITY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 647 - 657
SICI:
1074-7613(200110)15:4<647:TIANRO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; HUMAN-IMMUNODEFICIENCY-VIRUS; FACTOR RECEPTOR SUPERFAMILY; PROGRAMMED CELL-DEATH; T-CELLS; DEFECTIVE INTERLEUKIN-1; COSTIMULATORY MOLECULE; TARGETED DISRUPTION; INDUCED APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Tsitsikov, EN Harvard Univ, Sch Med, Div Immunol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 unol, Boston, MA 02115 USA
Citazione:
E.N. Tsitsikov et al., "TRAF1 is a negative regulator of TNF signaling: Enhanced TNF signaling in TRAF1-deficient mice", IMMUNITY, 15(4), 2001, pp. 647-657

Abstract

TNF receptor-associated factor 1 (TRAF1) is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in activated lymphocytes. To elucidate the function of TRAF1, we generated TRAF1-deficient mice. TRAF1(-/-) mice are viable and have normal lymphocyte development. TRAF1(-/-) T cells exhibit stronger than wild-type (WT) T cell proliferation to anti-CD3 mAb, which persisted in the presence of IL-2 or anti-CD28 antibodies. Activated TRAF1(-/-) T cells, but not TRAF1(+/+) T cells, responded to TNF by proliferation and activation of the NF-kappaB and AP-1 signaling pathways. This TNF effect was mediated by TNFR2 (p75) but not by TNFR1 (p55). Furthermore, skin from TRAF1(-/-) mice was hypersensitive to TNF-induced necrosis. These findings suggest that TRAF1 is a negative regulator of TNF signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:31:00