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Titolo:
Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells
Autore:
Varga, SM; Wang, XT; Welsh, RM; Braciale, TJ;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Beirne Carter Ctr Immunol Res, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Microbiol, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Pathol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Massachusetts, Med Ctr, Program Immunol & Virol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Virol, Worcester, MA 01655 USA Univ Massachusetts, Med Ctr, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Pathol, Worcester, MA 01655 USA
Titolo Testata:
IMMUNITY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 637 - 646
SICI:
1074-7613(200110)15:4<637:IIRIIM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; BALB/C MICE; LEISHMANIA-MAJOR; CYTOKINE SECRETION; VIRAL-INFECTION; G GLYCOPROTEIN; EOSINOPHILIA; RESPONSES; REPERTOIRE; DETERMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Braciale, TJ Univ Virginia, Hlth Sci Ctr, Beirne Carter Ctr Immunol Res, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 lle, VA 22908 USA
Citazione:
S.M. Varga et al., "Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells", IMMUNITY, 15(4), 2001, pp. 637-646

Abstract

Vaccination with the respiratory syncytial virus (RSV) attachment (G) protein results in immune-mediated lung injury after natural RSV infection withpathogenic features characteristic of an exaggerated Th2 response. Here wedemonstrate that approximately half of the CD4(+) T cells infiltrating thelungs of G-primed mice utilize a single VP gene (V beta 14) with remarkably limited CDR3 diversity. Furthermore, elimination of these V beta 14-bearing CD4(+) T cells in vivo abolishes the type 2-like pulmonary injury. Theseresults suggest that a novel subset of CD4(+) T cells may be crucial in the development of pathology during human RSV infection and that genetic or environmental factors prior to or at the time of G antigen exposure may affect the commitment of this discrete antigen-specific T cell subset to Th2 differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:39:35