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Titolo:
MHC class I ubiquitination by a viral PHD/LAP finger protein
Autore:
Boname, JM; Stevenson, PG;
Indirizzi:
Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP rol, Cambridge CB2 1QP, England
Titolo Testata:
IMMUNITY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 627 - 636
SICI:
1074-7613(200110)15:4<627:MCIUBA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SARCOMA-ASSOCIATED HERPESVIRUS; CD8(+) T-CELLS; ENDOPLASMIC-RETICULUM; GAMMA-HERPESVIRUS; HEAVY-CHAINS; MURINE GAMMAHERPESVIRUS-68; CD4-DEFICIENT MICE; MEMBRANE-PROTEINS; DOWN-REGULATION; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Stevenson, PG Univ Cambridge, Dept Pathol, Div Virol, Tennis Court Rd, Cambridge CB2 1QP, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP nd
Citazione:
J.M. Boname e P.G. Stevenson, "MHC class I ubiquitination by a viral PHD/LAP finger protein", IMMUNITY, 15(4), 2001, pp. 627-636

Abstract

The murine gamma -herpesvirus-68 K3 (MK3) is a PHD/LAP finger protein thatdownregulates major histocompatibility complex (MHC) class I expression. In transfected cell lines, MK3 was expressed in the endoplasmic reticulum (ER) membrane, where it bound the cytoplasmic tail of newly synthesized H-2D(b) glycoproteins and targeted them for degradation. Proteasome inhibitors blocked the degradation and led to an accumulation of ubiquitinated H-2D(b). Because this retained its native conformation, ubiquitination preceded anydenaturation or dislocation to the cytosol. The PHD/LAP finger of MK3 was not required for H-2D(b) binding but was essential for its ubiquitination and degradation. Thus, gamma -herpesviruses have adapted the cellular PHD/LAP motif to immune evasion, apparently for the catalysis of MHC class I ubiquitination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:34:42