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Titolo:
GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
Autore:
Shibata, Y; Berclaz, PY; Chroneos, ZC; Yoshida, M; Whitsett, JA; Trapnell, BC;
Indirizzi:
Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
IMMUNITY
fascicolo: 4, volume: 15, anno: 2001,
pagine: 557 - 567
SICI:
1074-7613(200110)15:4<557:GRAMDA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; TRANSCRIPTION FACTOR PU.1; FACTOR-DEFICIENT MICE; COMMON BETA-SUBUNIT; MYELOID DEVELOPMENT; GENE-EXPRESSION; GRANULOCYTE; PROLIFERATION; RECEPTOR; HEMATOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Trapnell, BC Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 cinnati, OH 45229 USA
Citazione:
Y. Shibata et al., "GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1", IMMUNITY, 15(4), 2001, pp. 557-567

Abstract

GM-CSF gene targeted (GM(-/-)) mice are susceptible to respiratory infections and develop alveolar proteinosis due to defects in innate immune function and surfactant catabolism in alveolar macrophages (AMs), respectively. Reduced cell adhesion, phagocytosis, pathogen killing, mannose- and Toll-like receptor expression, and LPS- or peptidoglycan-stimulated TNF alpha, release were observed in AMs from GM(-/-) mice. The transcription factor PU.1 was markedly reduced in AMs of GM(-/-) mice in vivo and was restored by selective expression of GM-CSF in the lungs of SPC-GM/GM(-/-) transgenic mice. Retrovirus-mediated expression of PU.1 in AMs from GM(-/-) mice rescued host defense functions and surfactant catabolism by AMs. We conclude that PU.1mediates GM-CSF-dependent effects on terminal differentiation of AMs regulating innate immune functions and surfactant catabolism by AMs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:27:47