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Titolo:
Heterogeneity of genetic alterations in prostate cancer: evidence of the complex nature of the disease
Autore:
Nwosu, V; Carpten, J; Trent, JM; Sheridan, R;
Indirizzi:
N Carolina Cent Univ, Dept Biol, Durham, NC 27707 USA N Carolina Cent Univ Durham NC USA 27707 Dept Biol, Durham, NC 27707 USA NHGRI, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892NHGRI, NIH, Bethesda, MD 20892 USA DNA Sci Labs, Morrisville, NC 27560 USA DNA Sci Labs Morrisville NC USA 27560 Sci Labs, Morrisville, NC 27560 USA
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 20, volume: 10, anno: 2001,
pagine: 2313 - 2318
SICI:
0964-6906(20011001)10:20<2313:HOGAIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANDROGEN RECEPTOR GENE; CAG REPEAT POLYMORPHISM; BULBAR MUSCULAR-ATROPHY; SUSCEPTIBILITY LOCUS; LINKAGE ANALYSIS; HIGH-RISK; CHROMOSOME 1Q42.2-43; ALLELIC IMBALANCE; FAMILY HISTORY; CLINICAL PRESENTATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Carpten, J N Carolina Cent Univ, Dept Biol, Durham, NC 27707 USA N Carolina Cent Univ Durham NC USA 27707 Durham, NC 27707 USA
Citazione:
V. Nwosu et al., "Heterogeneity of genetic alterations in prostate cancer: evidence of the complex nature of the disease", HUM MOL GEN, 10(20), 2001, pp. 2313-2318

Abstract

Prostate cancer is a complex, multifactorial disease with genetic and environmental factors involved in its etiology. The search for genetic determinants involved in the disease has proven to be challenging, in part because such complex diseases are often not amenable to characterization by linkageanalysis and positional cloning as is the case for diseases with simple Mendelian genetic inheritance. Prostate cancer susceptibility loci that have been reported so far include HPC1 (1q24-q25), PCAP (1q42-q43), HPCX (Xq27-q28), CAPB (1p36), HPC20 (20q13), HPC2/ELAC2 (17p11) and 16q23. Prostate cancer aggressiveness loci have also been reported (5q31-q33, 7q32 and 19q12). Further complicating the process is the existence of polymorphisms in several genes associated with prostate cancer including, AR, PSA, SRD5A2, VDR and CYP isoforms. These polymorphisms, however, are not thought to be highlypenetrant alleles in families at high risk for prostate cancer. It is clear that prostate cancer etiology involves several genetic loci with no majorgene accounting for a large proportion of susceptibility to the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:10:32