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Titolo:
Human diseases with underlying defects in chromatin structure and modification
Autore:
Hendrich, B; Bickmore, W;
Indirizzi:
Univ Edinburgh, Ctr Genome Res, Edinburgh EH9 3JQ, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 3JQ Midlothian, Scotland MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH4 2XU h EH4 2XU, Midlothian, Scotland
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 20, volume: 10, anno: 2001,
pagine: 2233 - 2242
SICI:
0964-6906(20011001)10:20<2233:HDWUDI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RUBINSTEIN-TAYBI-SYNDROME; LINKED MENTAL-RETARDATION; XNP/ATR-X GENE; TRANSCRIPTIONAL REGULATOR ATRX; DNA METHYLTRANSFERASE GENE; RETT-SYNDROME; ICF SYNDROME; HISTONE H3; CHROMOSOME INACTIVATION; REPRESS TRANSCRIPTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Hendrich, B Univ Edinburgh, Ctr Genome Res, Roger Land Bldg, Edinburgh EH93JQ, Midlothian, Scotland Univ Edinburgh Roger Land Bldg Edinburgh Midlothian Scotland EH9 3JQ
Citazione:
B. Hendrich e W. Bickmore, "Human diseases with underlying defects in chromatin structure and modification", HUM MOL GEN, 10(20), 2001, pp. 2233-2242

Abstract

Chromatin structure is important for regulating gene expression and for the proper condensation and segregation of chromosomes during cell division. Several human genetic diseases have been found to be due to mutations in genes producing proteins known or suspected to be involved in maintaining or modifying chromatin structure. Here we describe these 'chromatin diseases' and review what is known about the associated chromatin proteins in light of recent advances in the understanding of chromatin components, modification and function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:13:18