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Titolo:
Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)
Autore:
Frei, E; Gamma, A; Pascual-Marqui, R; Lehmann, D; Hell, D; Vollenweider, FX;
Indirizzi:
Univ Zurich, Hosp Psychiat, CH-8029 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8029 hiat, CH-8029 Zurich, Switzerland Univ Zurich, Hosp Psychiat, KEY Inst Brain Mind Res, Zurich, Switzerland Univ Zurich Zurich Switzerland Inst Brain Mind Res, Zurich, Switzerland
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 3, volume: 14, anno: 2001,
pagine: 152 - 165
SICI:
1065-9471(200111)14:3<152:LOMBAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPILEPTIC FOCUS; ECSTASY USERS; EEG; HUMANS; DRUG; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; SCHIZOPHRENIA; FENFLURAMINE; OSCILLATIONS; PROFILE;
Keywords:
3,4-methylenedioxymethamphetamine (MDMA); EEG; LORETA; power spectrum; Ecstasy; serotonin; mood; emotion; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Vollenweider, FX Univ Zurich, Hosp Psychiat, POB 68, CH-8029 Zurich, Switzerland Univ Zurich POB 68 Zurich Switzerland CH-8029 witzerland
Citazione:
E. Frei et al., "Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)", HUM BRAIN M, 14(3), 2001, pp. 152-165

Abstract

3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and neurophysiological basis of acute MDMA effects remains unknown. The distribution of active neuronal populations after administration of a single dose of MDMA (1.7 mg/kg) or placebo was studied in 16 healthy, MDMA-naive volunteers. Thirty-one-channel scalp EEGs during resting withopen and closed eyes was analyzed in the different EEG frequency bands. Scalp maps of power showed significant, global differences between MDMA and placebo in both eye conditions and all frequency bands. Low resolution brainelectromagnetic tomography (LORETA) was used to compute 3D, functional images of electric neuronal activity from the scalp EEG data. MDMA produced a widespread decrease of slow and medium frequency activity and an increase of fast frequency activity in the anterior temporal and posterior orbital cortex, concomitant with a marked enhancement of mood, emotional arousal and increased extraversion. This activation of frontotemporal areas indicates that the observed enhancement of mood and possibly the increased extroversion rely on modulation of limbic orbitofrontal and anterotemporal structures known to be involved in emotional processes. Comparison of the MDMA-specific EEG pattern with that of various 5-HT, DA, and NA agonists indicates thatserotonin, noradrenaline, and, to a lesser degree, dopamine, contribute tothe effects of MDMA on EEG, and possibly also on mood and behavior. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:27:27