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Titolo:
Leptin concentrations are elevated in newborn infants of diabetic mothers
Autore:
Tapanainen, P; Leinonen, E; Ruokonen, A; Knip, M;
Indirizzi:
Univ Oulu, Dept Pediat, FIN-90230 Oulu, Finland Univ Oulu Oulu Finland FIN-90230 u, Dept Pediat, FIN-90230 Oulu, Finland Univ Oulu, Dept Clin Chem, FIN-90230 Oulu, Finland Univ Oulu Oulu Finland FIN-90230 Dept Clin Chem, FIN-90230 Oulu, Finland Univ Helsinki, Hosp Children & Adolescents, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ts, FIN-00014 Helsinki, Finland
Titolo Testata:
HORMONE RESEARCH
fascicolo: 4, volume: 55, anno: 2001,
pagine: 185 - 190
SICI:
0301-0163(2001)55:4<185:LCAEIN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; CORD-BLOOD; SERUM LEPTIN; BIRTH-WEIGHT; OB GENE; OBESE GENE; INSULIN; GENDER; CHILDREN; MACROSOMIA;
Keywords:
diabetes; infants; leptin; fetal growth; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Tapanainen, P Univ Oulu, Dept Pediat, FIN-90230 Oulu, Finland Univ Oulu Oulu Finland FIN-90230 , FIN-90230 Oulu, Finland
Citazione:
P. Tapanainen et al., "Leptin concentrations are elevated in newborn infants of diabetic mothers", HORMONE RES, 55(4), 2001, pp. 185-190

Abstract

Background., Infants of diabetic mothers have been characterized by macrosomia due to hyperinsulinism. A relation has been observed between circulating levels of leptin and the intrauterine growth pattern. Methods: We studied the leptin and insulin concentrations in the cord blood of 29 newborn infants of mothers with type 1 diabetes (iT1DM), 70 newborn infants of motherswith gestational diabetes and 105 newborn infants of nondiabetic mothers. Results: There were significant differences (p < 0.001) between the 3 groups with the highest leptin levels 24.9 mug/I (range 1.7-94.1) in infants of mothers with iT1DM and the second-highest levels 14.0 mug/l (range 2.6-74.9) in infants of mothers with gestational diabetes (iGDM), whereas the control infants had the lowest leptin levels 10.0 mug/l (range 0.10-45.9). Girlshad higher leptin concentrations than boys among the iT1DM and control infants. The insulin concentrations were 18.1 mU/I (range 1.9-123.3), 6.1 mU/I(range 1.1-51.4) and 3.6 mU/I (range 0.5-21.5) in the 3 groups (p < 0.001), respectively. A significant correlation was observed between leptin and insulin concentrations in iGDM and control infants (r = 0.51; p < 0.001 and r = 0.25; p < 0.05). Both absolute and relative birth weights correlated with leptin levels in all 3 groups (r = 0.60, p = 0.01 and r = 0.51, p = 0.05in iT1DM; r = 0.51 and 0.56, p < 0.001 in iGDM and r = 0.42 and 0.59, p < 0.001 in control infants). Conclusion: Our results confirm the relation between leptin concentrations and birth weight. They also suggest that leptin may be involved in the increased accumulation of adipose tissue characteristic of infants of diabetic mothers. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:35:29