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Titolo:
Growth patterns and final height in congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency - Results of a multicenter study
Autore:
Hargitai, G; Solyom, J; Battelino, T; Lebl, J; Pribilincova, Z; Hauspie, R; Kovacs, J; Waldhauser, F; Frisch, H;
Indirizzi:
Univ Vienna, Dept Pediat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Pediat, A-1090 Vienna, Austria Semmelweis Univ Med, Dept Pediat 2, H-1085 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1085 2, H-1085 Budapest, Hungary Lorand Eotvos Univ, Dept Biol Anthropol, H-1445 Budapest, Hungary Lorand Eotvos Univ Budapest Hungary H-1445 pol, H-1445 Budapest, Hungary Univ Szeged, Dept Pediat, H-6720 Szeged, Hungary Univ Szeged Szeged Hungary H-6720 d, Dept Pediat, H-6720 Szeged, Hungary Univ Ljubljana, Childrens Hosp, Med Ctr, Dept Pediat Endocrinol Diabet & Metab Dis, Ljubljana 61111, Slovenia Univ Ljubljana Ljubljana Slovenia 61111 b Dis, Ljubljana 61111, Slovenia Charles Univ, Fac Med 3, Dept Pediat, CR-18000 Prague, Czech Republic Charles Univ Prague Czech Republic CR-18000 18000 Prague, Czech Republic Univ Childrens Hosp, Dept Pediat 2, Bratislava, Slovakia Univ Childrens Hosp Bratislava Slovakia Pediat 2, Bratislava, Slovakia Free Univ Brussels, Lab Anthropogenet, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 net, B-1090 Brussels, Belgium
Titolo Testata:
HORMONE RESEARCH
fascicolo: 4, volume: 55, anno: 2001,
pagine: 161 - 171
SICI:
0301-0163(2001)55:4<161:GPAFHI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL PRECOCIOUS PUBERTY; ADULT HEIGHT; EXPERIENCE; THERAPY; FERTILITY; CHILDHOOD; CORTISOL; ANALOG; WOMEN;
Keywords:
congenital adrenal hyperplasia; body height percentiles; growth velocity; pubertal growth spurt; final height;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Frisch, H Univ Vienna, Dept Pediat, Waehringer Str 18-22, A-1090 Vienna, Austria Univ Vienna Waehringer Str 18-22 Vienna Austria A-1090 Austria
Citazione:
G. Hargitai et al., "Growth patterns and final height in congenital adrenal hyperplasia due to classical 21-hydroxylase deficiency - Results of a multicenter study", HORMONE RES, 55(4), 2001, pp. 161-171

Abstract

Background. Longitudinal growth and bone age (BA) development are the mostimportant clinical parameters for monitoring adequate glucocorticoid replacement in children with congenital adrenal hyperplasia (CAH). Aim of the Study. To analyze the growth pattern of patients treated for CAH of the salt wasting (SW) and simple virilizing (SV) clinical forms; to evaluate final height as compared to reference data and individual target height; to evaluate the course of BA development. Patients and Methods: A large database of 598 patients with CAH was created in 5 Central European countries and growth data of 341 treated patients with 21-hydroxylase deficiency were analyzedretrospectively. The patients were of Caucasian origin. Centiles were constructed in a cross-sectional manner and an additional longitudinal analysiswas performed in order to evaluate the pubertal growth spurt by applying particular statistical methods (Preece-Baines model). Results: The growth ofSW CAH patients was impaired in infancy and early childhood (0-3 years of age), but followed normal patterns in childhood until puberty. In contrast,children with SV CAH had normal patterns of growth in infancy and early childhood and were considerably taller than healthy references during childhood. In the longitudinal study, peak height velocity in both boys and girls was normal, but it occurred at an earlier age than in the standard population. The final height of patients with CAH was reduced in comparison to boththe reference and the individual target height. No correlations were foundbetween final height and age at the start of the therapy in SV patients orbetween final height and year of birth. BA was advanced in both types of CAH, but more accelerated in SV patients. Conclusion: Characteristic growth patterns for treated SV and SW CAH children were identified, with a normal pubertal growth spurt and reduced final height being observed. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 29/03/20 alle ore 13:27:21