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Titolo:
Triglyceride-rich lipoprotein cholesterol exceeds low-density lipoprotein cholesterol in hypertriglyceridemia patients
Autore:
Ai, M; Tanaka, A; Tomie, N; Ogita, K; Sekine, M; Numano, F; Numano, F;
Indirizzi:
Tokyo Med & Dent Univ, Dept Internal Med 3, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Tokyo Metropolitan Kiyose Hosp, Dept Internal Med, Tokyo, Japan Tokyo Metropolitan Kiyose Hosp Tokyo Japan t Internal Med, Tokyo, Japan
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 10, volume: 33, anno: 2001,
pagine: 612 - 617
SICI:
0018-5043(200110)33:10<612:TLCELL>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LDL CHOLESTEROL; APOLIPOPROTEIN-B-100; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; ASSOCIATION;
Keywords:
triglyceride; hypercholesterolemia; hypertriglyceridemia; triglyceride-rich lipoprotein; arteriosclerosis; apolipoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, A Tokyo Med & Dent Univ, Dept Internal Med 3, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 Japan
Citazione:
M. Ai et al., "Triglyceride-rich lipoprotein cholesterol exceeds low-density lipoprotein cholesterol in hypertriglyceridemia patients", HORMONE MET, 33(10), 2001, pp. 612-617

Abstract

The atherogenicity of triglyceride-rich lipoprotein has been revealed. This study was performed to explore the clinical importance of trig lyceride-rich lipoprotein by measuring its cholesterol content and comparing it with other lipoprotein fractions. Blood samples were obtained from 103 patients whose fasting plasma triglyceride concentration exceeded 300 mg/dl. The cholesterol monitor using the technique of high-performance liquid chromatography was used for the measurement of their plasma cholesterol concentrationsand the determination of cholesterol distribution among lipoprotein fractions. This monitor showed 4 peaks: large-triglyceride-rich lipoprotein, small-triglyceride-rich lipoprotein, low-density lipoprotein, and high-density lipoprotein. Total cholesterol increased with increasing triglyceride. The increment of total cholesterol was nearly equal to that of small-triglyceride-rich lipoprotein cholesterol. Small-triglycericle-rich lipoprotein cholesterol exceeded low-density lipoprotein cholesterol where plasma triglycericle concentration was over 500 mg/dl. In conclusion, triglyceride-rich lipoprotein may be clinically important for hypertriglyceridemic patients as a source of cholesteryl ester in arteriosclerotic plaques, and increased triglyceride-rich lipoprotein cholesterol may be used as a basis for hypertriglyceridemia atherogenicity. Our study suggests that hypertriglyceridemia should be treated to prevent arteriosclerotic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:35:40