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Titolo:
Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial
Autore:
Mulder, HJGH; Schalij, MJ; Kauer, B; Visser, RF; van Dijkman, PRM; Jukema, JW; Zwinderman, AH; Bruschke, AVG;
Indirizzi:
Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Dept Med Stat, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands St Elizabeth Hosp, Leiderdorp, Netherlands St Elizabeth Hosp Leiderdorp Netherlands Hosp, Leiderdorp, Netherlands St Joseph Hosp, Veldhoven, Netherlands St Joseph Hosp Veldhoven Netherlands oseph Hosp, Veldhoven, Netherlands Bronovo Hosp, The Hague, Netherlands Bronovo Hosp The Hague NetherlandsBronovo Hosp, The Hague, Netherlands
Titolo Testata:
HEART
fascicolo: 5, volume: 86, anno: 2001,
pagine: 533 - 539
SICI:
1355-6037(200111)86:5<533:PAEDVA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL-LOWERING THERAPY; ARTERY DISEASE; BALLOON ANGIOPLASTY; RESTENOSIS; INJURY; ACETYLCHOLINE; DYSFUNCTION; HYPERCHOLESTEROLEMIA; VASOCONSTRICTION; REGRESS;
Keywords:
angioplasty; endothelium; acetylcholine; pravastatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Schalij, MJ Leiden Univ, Med Ctr, Dept Cardiol, Albinusdreef 2,POB 9600, NL-2300 RC Leiden, Netherlands Leiden Univ Albinusdreef 2,POB 9600 Leiden Netherlands NL-2300 RC
Citazione:
H.J.G.H. Mulder et al., "Pravastatin and endothelium dependent vasomotion after coronary angioplasty: the PREFACE trial", HEART, 86(5), 2001, pp. 533-539

Abstract

Objective To test the hypothesis that the 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor pravastatin ameliorates endothelium mediated responses of dilated coronary segments: the PREFACE (pravastatin related effects following angioplasty on coronary endothelium) trial. Design-A double blind, randomised, placebo controlled, multicentre study. Setting Four hospitals in the Netherlands. Patients-63 non-smoking, non-hypercholesterolaemic patients scheduled for elective balloon angioplasty (pravastatin 34, placebo 29). Interventions-The effects of three months of pravastatin treatment (40 mg daily) on endothelium dependent vasomotor function were studied. Balloon angioplasty was undertaken one month after randomisation, and coronary vasomotor function tests using acetylcholine were performed two months after balloon angioplasty. The angiograms were analysed quantitatively. Main outcome measures-The efficacy measure was the acetylcholine induced change in mean arterial diameter, determined in the dilated segment and in an angiographically normal segment of an adjacent non-manipulated coronary artery. Results-Increasing acetylcholine doses produced vasoconstriction in the dilated segments (p = 0.004) but not in the normal segments. Pravastatin did not affect the vascular response to acetylcholine in either the dilated segments (p = 0.09) or the non-dilated sites. Endothelium dependent vasomotionin normal segments was correlated with that in dilated segments (r = 0.47,p < 0.001). There were fewer procedure related events in the pravastatin group than in the placebo group (p < 0.05). Conclusions-Endothelium dependent vasomotion in normal segments is correlated with that in dilated segments. A significant beneficial effect of pravastatin on endothelial function could not be shown, but in the dilated segments there was a trend towards a beneficial treatment effect in the pravastatin group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 12:54:22