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Titolo:
The Harvard Twin Study of Substance Abuse: What we have learned
Autore:
Tsuang, MT; Bar, JL; Harley, RM; Lyons, MJ;
Indirizzi:
Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr Boston MA USA 02115 r, Boston, MA 02115 USA Boston Univ, Dept Psychol, Boston, MA 02215 USA Boston Univ Boston MA USA02215 Univ, Dept Psychol, Boston, MA 02215 USA Harvard Univ, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Epidemiol & Genet, Boston, MA 02115 USA
Titolo Testata:
HARVARD REVIEW OF PSYCHIATRY
fascicolo: 6, volume: 9, anno: 2001,
pagine: 267 - 279
SICI:
1067-3229(200111/12)9:6<267:THTSOS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-DEPENDENT INDIVIDUALS; ENVIRONMENTAL-INFLUENCES; CONDUCT DISORDER; DRUG-ABUSE; PSYCHIATRIC-DISORDERS; SMOKING PERSISTENCE; MAJOR DEPRESSION; GENETIC MODELS; VET REGISTRY; RISK-FACTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuang, MT Massachusetts Mental Hlth Ctr, 74 Fenwood Rd, Boston, MA 02115 USA Massachusetts Mental Hlth Ctr 74 Fenwood Rd Boston MA USA 02115
Citazione:
M.T. Tsuang et al., "The Harvard Twin Study of Substance Abuse: What we have learned", HARV R PSYC, 9(6), 2001, pp. 267-279

Abstract

The Harvard Twin Study of Substance Abuse was carried out with the membersof the Vietnam Era Twin (VET) Registry. The VET Registry comprises over 8000 male twins who served in the United States military between 1965 and 1975 and were subsequently interviewed regarding their use of licit and illicit substances, as well as various types of psychopathology. Our research hasdemonstrated significant influences by genetic, shared environmental, and unique environmental factors on the abuse of illicit substances. Multivariate analyses have indicated that the co-occurrence of abuse of various typesof illicit drugs reflects a common vulnerability, influenced by both genetic and environmental factors, that cuts across all categories of illicit drugs. We have also demonstrated that some drugs have unique determinants, both genetic and environmental, that are not shared with other drugs. In part, the genetic influence on marijuana abuse is mediated by genetic influenceon subjective effects in response to the drug. The determinants of transitions from one stage of drug use to another differ depending on which drug or which transition is examined. We determined significant genetic influences on several aspects of nicotine and alcohol use separately, as well as genetic influences shared by both substances. We found that the co-occurrence of illicit drug abuse and major depression is due to unique environmental influences. The phenotypic association between symptoms of conduct disorder and alcohol and marijuana dependence is due largely to shared environmentalinfluences. Our results, thus far, indicate a complex pattern of genetic and environmental influences on substance use and abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:53:01