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Titolo:
Activated protein C resistance in Turkish women with severe preeclampsia
Autore:
Cetin, M; Gucer, S; Serin, IS; Eser, B; Tayyar, M; Unal, A;
Indirizzi:
Erciyes Univ, Sch Med, Dept Internal Med, Div Hematol, TR-38039 Kayseri, Turkey Erciyes Univ Kayseri Turkey TR-38039 v Hematol, TR-38039 Kayseri, Turkey Erciyes Univ, Sch Med, Dept Obstet & Gynecol, TR-38039 Kayseri, Turkey Erciyes Univ Kayseri Turkey TR-38039 & Gynecol, TR-38039 Kayseri, Turkey
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
fascicolo: 3, volume: 52, anno: 2001,
pagine: 168 - 172
SICI:
0378-7346(2001)52:3<168:APCRIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V GENE; VENOUS THROMBOSIS; INHERITED RESISTANCE; PREGNANCY; MUTATION;
Keywords:
activated protein C resistance; preeclampsia; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Cetin, M Erciyes Univ, Sch Med, Dedeman Hematol Oncol Hosp, TR-38039 Kayseri, Turkey Erciyes Univ Kayseri Turkey TR-38039 , TR-38039 Kayseri, Turkey
Citazione:
M. Cetin et al., "Activated protein C resistance in Turkish women with severe preeclampsia", GYNECOL OBS, 52(3), 2001, pp. 168-172

Abstract

The purpose of this study was to investigate the occurrence rate of APC resistance (APC-R) with severe preeclampsia in Turkish women. Thirty-two consecutive women having severe preeclampsia were included in the study. Thirty-two healthy pregnant women served as the control group. APC-R assays were performed in the third trimester of pregnancy, and 3 and 9 months after delivery. APC-R was demonstrated in the third trimester, 3 months and 9 monthsafter delivery in 27 (84.4%), 23 (71.9%) and 5 (15.6%) of 32 preeclamptic patients, respectively. APC-R rates were significantly higher in preeclamptic group than in normal pregnant women in the third trimester of pregnancy (p < 0.05). Decreased mean APC activity and also increased APC-R rate was still persisting in preeclamptic group for 3 months after delivery. Nine months after delivery, the mean APC activity and also APC-R rates approached to the normal pregnant women; however, there was a significant difference between both groups (p < 0.05). Our results indicate that acquired APC-R may be a contributory factor in the pathogenesis of preeclampsia. Copyright (C)2001 S, Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:34:17