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Titolo:
Dynamics of microsatellite divergence under stepwise mutation and proportional slippage/point mutation models
Autore:
Calabrese, PP; Durrett, RT; Aquadro, CF;
Indirizzi:
Cornell Univ, Dept Math, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 ll Univ, Dept Math, Ithaca, NY 14853 USA Cornell Univ, Dept Appl Math, Ithaca, NY 14853 USA Cornell Univ Ithaca NYUSA 14853 iv, Dept Appl Math, Ithaca, NY 14853 USA Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 t Mol Biol & Genet, Ithaca, NY 14853 USA
Titolo Testata:
GENETICS
fascicolo: 2, volume: 159, anno: 2001,
pagine: 839 - 852
SICI:
0016-6731(200110)159:2<839:DOMDUS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOGASTER SPECIES COMPLEX; DROSOPHILA-MELANOGASTER; SACCHAROMYCES-CEREVISIAE; GENETIC DISTANCES; RANGE CONSTRAINTS; POINT MUTATIONS; TANDEM REPEAT; ALLELE SIZE; LOCI; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Calabrese, PP Cornell Univ, Dept Math, 523 Malott Hall, Ithaca, NY 14853 USA Cornell Univ 523 Malott Hall Ithaca NY USA 14853 Y 14853 USA
Citazione:
P.P. Calabrese et al., "Dynamics of microsatellite divergence under stepwise mutation and proportional slippage/point mutation models", GENETICS, 159(2), 2001, pp. 839-852

Abstract

Recently Kruglyak, Durrett, Schug, and Aquadro showed that microsatellite equilibrium distributions can result from a balance between polymerase slippage and point Mutations. Here, we introduce an elaboration of their model that keeps track of all parts of a perfect repeat and a simplification thatignores point mutations. We develop a detailed mathematical theory for these models that exhibits properties of microsatellite distributions, such aspositive skewness of allele lengths, that are consistent with data but areinconsistent with the predictions of the stepwise mutation model. We use our theoretical results to analyze the successes and failures of the geneticdistances (delta mu)(2) and D-SW when used to date four divergences: African vs. non-African human populations, humans vs. chimpanzees, Drosophila melanogaster vs. D. simulans, and sheep vs. cattle. The influence of point mutations explains some of the problems with the last two examples, as does the fact that these genetic distances have large stochastic variance. However, we find that these two features are not enough to explain the problems of dating the human-chimpanzee split. One possible explanation of this phenomenon is that long microsatellites have a mutational bias that favors contractions over expansions.

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Documento generato il 01/10/20 alle ore 01:29:36