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Titolo:
Recent advances in feeding suppressing agents: potential therapeutic strategy for the treatment of obesity
Autore:
Chaki, S; Nakazato, A;
Indirizzi:
Taisho Pharmaceut Co Ltd, Med Pharmacol Lab, Saitama, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Saitama Saitama Japan 3308530 ama 3308530, Japan Taisho Pharmaceut Co Ltd, Med Res Labs, Med Chem Lab, Saitama, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Saitama Saitama Japan 3308530 ama 3308530, Japan
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 11, volume: 11, anno: 2001,
pagine: 1677 - 1692
SICI:
1354-3776(200111)11:11<1677:RAIFSA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; MELANIN-CONCENTRATING-HORMONE; CENTRAL-NERVOUS-SYSTEM; PROTEIN-COUPLED RECEPTOR; NEUROPEPTIDE-Y RECEPTOR; FOOD-INTAKE; MOLECULAR-CLONING; GALANIN RECEPTOR; MICE LACKING; BODY-WEIGHT;
Keywords:
5-HT2C receptor agonists; anti-obesity agents; CCK receptor agonists; CRF receptor agonists; galanin receptor antagonists; leptin; MC4 receptor agonists; MCH receptor antagonists; neuropeptide Y receptor antagonists; orexin receptor antagonists;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
198
Recensione:
Indirizzi per estratti:
Indirizzo: Chaki, S Taisho Pharmaceut Co Ltd, Med Pharmacol Lab, 1-403 Yoshino Cho, Saitama, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd 1-403 Yoshino Cho Saitama Saitama Japan 3308530
Citazione:
S. Chaki e A. Nakazato, "Recent advances in feeding suppressing agents: potential therapeutic strategy for the treatment of obesity", EXPERT OP T, 11(11), 2001, pp. 1677-1692

Abstract

Obesity is an increasingly prevalent health problem for which no ideal treatments are available, especially for long-term maintenance of body loss. The only approved drugs are centrally acting appetite suppressants that modulate monoamine neurotransmitters in the brain. Since the discovery of leptin, and the fact it modulates neuropeptide systems in the CNS, attention hasshifted from amines to peptides. Many researchers have focused on these neuropeptide systems in the CNS and their involvement in energy balance. Withan effort to identify molecules involved in feeding behaviour and energy expenditure in the brain, especially in the hypothalamic nuclei, a series ofnovel potential targets for the development of anti-obesity agents, as well as potential drug candidates, are being given attention. Many pharmaceutical companies have large programmes directed at the development of new modulators of neuropeptide receptors, antagonists of appetite enhancing peptides and agonists of appetite suppressing peptides, including neuropeptide Y receptors and melanocortin receptors. This review covers recent targets for drug discovery of anti-obesity agents and patents focusing on the receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:37:19