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Titolo:
Role of cortical feedback in the receptive field structure and nonlinear response properties of somatosensory thalamic neurons
Autore:
Ghazanfar, AA; Krupa, DJ; Nicolelis, MAL;
Indirizzi:
Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA Max Planck Inst Biol Cybernet, D-72076 Tubingen, Germany Max Planck Inst Biol Cybernet Tubingen Germany D-72076 Tubingen, Germany
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 141, anno: 2001,
pagine: 88 - 100
SICI:
0014-4819(200111)141:1<88:ROCFIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMBINATION-SENSITIVE NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; POSTERIOR MEDIAL NUCLEUS; BARREL CORTEX; VENTRAL POSTERIOR; AUDITORY-CORTEX; RAT THALAMUS; CORTICOTHALAMIC PROJECTIONS; CORTICOFUGAL MODULATION; VISUAL-CORTEX;
Keywords:
corticothalamic; corticofugal; combination sensitivity; dynamic receptive fields; barrel cortex; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ghazanfar, AA Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 urobiol, Durham, NC 27710 USA
Citazione:
A.A. Ghazanfar et al., "Role of cortical feedback in the receptive field structure and nonlinear response properties of somatosensory thalamic neurons", EXP BRAIN R, 141(1), 2001, pp. 88-100

Abstract

Previous studies have suggested that the descending pathway from the primary somatosensory (Sl) cortex to the ventral posterior nucleus of the thalamus has only a mild facilitative influence over thalamic neurons. Given the large numbers of corticothalamic terminations within the rat somatosensory thalamus and their complex topography, we sought to examine the role of corticothalamic feedback in the genesis of spatiotemporal receptive fields andthe integration of complex tactile stimuli in the thalamus. By combining focal cortical inactivation (produced by microinjection of the GABAA agonistmuscimol), with chronic multielectrode recordings, we observed that feedback from the rat Sl cortex has multiple influences on its primary thalamic relay, the ventral posterior medial (VPM) nucleus. Our data demonstrate that, when single-whisker stimuli were used, the elimination of cortical feedback caused significant changes in the spatiotemporal structure of the receptive fields of VPM neurons. Cortical feedback also accounted for the nonlinear summation of VPM neural responses to simultaneously stimulated whiskers,in effect "linearizing" the responses. These results argue that the integration and transmission of tactile information through VPM are strongly influenced by the state of Sl cortex.

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Documento generato il 30/11/20 alle ore 23:37:48