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Titolo:
EFFECT OF RP DIASTEREOISOMER OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHOTHIOATE ON THE CAMP-DEPENDENT RELAXATION OF SMOOTH-MUSCLE
Autore:
PEREZVALLINA JR; REVUELTA MP; CANTABRANA B; HIDALGO A;
Indirizzi:
FAC MED,DEPT MED,FARMACOL LAB,C JULIAN CLAVERIA 6 OVIEDO 33006 SPAIN FAC MED,DEPT MED,FARMACOL LAB OVIEDO 33006 SPAIN
Titolo Testata:
Life sciences
fascicolo: 9, volume: 61, anno: 1997,
pagine: 869 - 880
SICI:
0024-3205(1997)61:9<869:EORDOA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE PHOSPHODIESTERASES; SELECTIVE INHIBITORS; UTERINE CONTRACTION; ADENYLYL CYCLASE; RAT; AMP; FORSKOLIN; MYOMETRIUM; ANTAGONISTS; NEURONS;
Keywords:
RP-CAMPS; 8-BRCAMP; HISTAMINE; PAPAVERINE; CAMP-DEPENDENT PROTEIN KINASE; SMOOTH MUSCLE CONTRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Perezvallina et al., "EFFECT OF RP DIASTEREOISOMER OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHOTHIOATE ON THE CAMP-DEPENDENT RELAXATION OF SMOOTH-MUSCLE", Life sciences, 61(9), 1997, pp. 869-880

Abstract

The effect of Rp diastereoisomer of adenosine 3',5'-cyclic monophosphothioate (Rp-cAMPS) on relaxation elicited by histamine (1-100 mu m), forskolin (1-60 mu M), papaverine (1-100 mu M), vinpocetine (1-100 mu M), rolipram (0.1-1 mM), Sp-cAMPS (10-300 mu M), 8-BrcAMP (10 mu M-1 mM) and 8-BrcGMP (3 mu M-1 mM) of the previous vanadate-induced contraction was assayed. The effect of Rp-cAMPS on the relaxing effect produced by forskolin, papaverine, vinpocetine, rolipram, Sp-cAMPS and 8-BrcAMP in Kcl-induced tonic contraction was also assayed. Histamine, forskolin, papaverine, rolipram, Sp-cAMPS, 8-BrcAMP and 8-BrcGMP, but not vinpocetine, relaxed the vanadate-induced contractions in rat uterus incubated in medium lacking calcium plus EDTA in a concentration-dependent way. Rp-cAMPS (1-300 mu M) had no effect on vanadate contraction. However, it antagonized the relaxation elicited by histamine and papaverine, but not that of forskolin, rolipram, Sp-cAMPS, 8-BrcAMP and 8-BrcGMP. Forskolin, papaverine, vinpocetine, rolipram and 8-BrcAMP, but not Sp-cAMPS, relaxed the KCl-induced contraction. Rp-cAMPS antagonized the relaxation elicited by forskolin, papaverine and vinpocetine, but not that of rolipram and 8-BrcAMP. Our results suggest that: a) Rp-cAMPS is an effective PKA inhibitor that could be used to study the involvement of cAMP on drug-induced response in smooth muscle, and b) theeffects of Sp-cAMPS, 8-BrcAMP and rolipram were independent of the activation of protein kinases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:11:37