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Titolo:
Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics
Autore:
Moritz, S; Andresen, B; Jacobsen, D; Mersmann, K; Wilke, U; Lambert, M; Naber, D; Krausz, M;
Indirizzi:
Univ Hamburg, Krankenhaus Eppendorf, Klin Psychiat & Psychotherapie, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 otherapie, D-20246 Hamburg, Germany
Titolo Testata:
EUROPEAN PSYCHIATRY
fascicolo: 6, volume: 16, anno: 2001,
pagine: 354 - 361
SICI:
0924-9338(200109)16:6<354:NCOSSI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; EXTRAPYRAMIDAL SYMPTOMS; COGNITIVE DYSFUNCTION; MENTAL PROCESSES; PERFORMANCE; DISORDERS; DICHOTOMY; VALIDITY;
Keywords:
atypical neuroleptics; disorganization; negative symptoms; neuropsychology; positive symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Moritz, S Univ Hamburg, Krankenhaus Eppendorf, Klin Psychiat & Psychotherapie, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 urg, Germany
Citazione:
S. Moritz et al., "Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics", EUR PSYCHIA, 16(6), 2001, pp. 354-361

Abstract

There is widespread evidence that schizophrenic symptomatology is best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samplespredominantly treated with typical neuroleptics, which frequently induce parkinsonian symptoms that are hard to disentangle from primary negative symptoms and may have inflated correlations with neurocognition. A newly developed psychopathological instrument called the Positive and Negative and Disorganized Symptoms Scale (PANADSS) was evaluated in 60 schizophrenic patients. Forty-seven participants treated with atypical neuroleptics performed several neurocognitive tasks. A three-factor solution of schizophrenic symptomatology emerged. Negative symptomatology was associated with diminished creative verbal fluency and digit span backward, whereas disorganization was significantly correlated with impaired Stroop, WCST and Trail-Making Test B performance. Data suggest that disorganization is associated with tasks that demand executive functioning. Previous findings reporting correlations between negative symptomatology and neurocognition may have been confounded by the adverse consequences of typical neuroleptics. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:16:54