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Titolo:
Understanding inflammatory bowel disease - The clinician's perspective
Autore:
Rutgeerts, P; Geboes, K;
Indirizzi:
Katholieke Univ Leuven Hosp, Dept Med, Louvain, Belgium Katholieke Univ Leuven Hosp Louvain Belgium Dept Med, Louvain, Belgium Katholieke Univ Leuven Hosp, Dept Pathol, Louvain, Belgium Katholieke UnivLeuven Hosp Louvain Belgium pt Pathol, Louvain, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
, volume: 167, anno: 2001, supplemento:, 586
pagine: 66 - 72
SICI:
1102-4151(200108)167:<66:UIBD-T>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; CEREVISIAE MANNAN ANTIBODIES; RECURRENT CROHNS-DISEASE; TERM FOLLOW-UP; ULCERATIVE-COLITIS; NEUTROPHIL AUTOANTIBODIES; INTESTINAL INFLAMMATION; FAMILIAL AGGREGATION; NATURAL-HISTORY; T-CELLS;
Keywords:
Crohn's disease; etiopathogenesis; therapy; ulcerative colitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Rutgeerts, P Univ Hosp Gasthuisberg, Dept Gastroenterol, Herestr 49, BL-3000 Louvain, Belgium Univ Hosp Gasthuisberg Herestr 49 Louvain Belgium BL-3000 um
Citazione:
P. Rutgeerts e K. Geboes, "Understanding inflammatory bowel disease - The clinician's perspective", EURO J SURG, 167, 2001, pp. 66-72

Abstract

The treatment of patients with ulcerative colitis and Crohn's disease is ahuge challenge to the clinician mainly because the etiology of IBD is still completely unknown. Pathogenetic mechanisms, in constrast, have partly been elucidated thanks to immunohistochemical investigation of the tissue in IBD and the study of experimental animal models of gut inflammation. There is extensive evidence that at least in Crohn's disease tolerance for commensal bacteria is lost which leads to uncontrolled inflammation mediated by aT-helper 1 response and to tissue destruction of the gut epithelium with inadequate repair. Genetic factors are probably responsible for increased susceptibility and may define disease phenotypes. These insights have led to a dramatic improvement of our therapeutic means with the development of thechimeric monoclonal antibody to TNF. The pathogenetic mechanisms are less clear in UC. The hypothesis is that UC is a T-helper 2 mediated disease. Wehave a very attractive way to study the early onset of Crohn's disease in the postoperative Crohn's situation. Newer therapeutic approaches should aim at preventing recurrence of Crohn's lesions in the normal postoperative bowel. Such model is also available for UC since there is increasing evidence that pouchitis is recurrent ulcerative colitis in the small bowel. Cooperation between clinicians and basic scientists is the best way to achieve fast progress in understanding IBD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:29:55