Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Helicobacter pylori and NSAIDs - What interaction
Autore:
McCarthy, DM;
Indirizzi:
Univ New Mexico, HSC, Div Gastroenterol & Hepatol, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 patol, Albuquerque, NM 87131 USA Vet Adm Med Ctr, Albuquerque, NM 87108 USA Vet Adm Med Ctr Albuquerque NMUSA 87108 d Ctr, Albuquerque, NM 87108 USA
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
, volume: 167, anno: 2001, supplemento:, 586
pagine: 56 - 65
SICI:
1102-4151(200108)167:<56:HPAN-W>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-DOSE ASPIRIN; PEPTIC-ULCERS; GASTRODUODENAL INJURY; INDUCED GASTROPATHY; CHEMICAL GASTRITIS; MUCOSAL INJURY; RISK-FACTORS; INFECTION; ERADICATION;
Keywords:
aspirin; H. pylori; proton pump inhibitor; cox(2)-selective; aspirin; non-steroidal anti-inflammatory drugs (NSAIDS); ulcers; perforated ulcers; bleeding; gastritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: McCarthy, DM USAF, Med Ctr, 111F,1501 San Pedro Blvd SE, Albuquerque, NM 87108 USA USAF 111F,1501 San Pedro Blvd SE Albuquerque NM USA 87108 USA
Citazione:
D.M. McCarthy, "Helicobacter pylori and NSAIDs - What interaction", EURO J SURG, 167, 2001, pp. 56-65

Abstract

Much controversy surrounds the interaction of Helicobacter pylori infection and the use of Aspirin (ASA) or non-aspirin nonsteroidal anti-inflammatory drugs (NANSAIDs). The issue is comprised of many components, best dealt with singly. In summary, the severity of drug-associated gastritis, but not its incidence or prevalence, is influenced by infection prior to ASA or NANSAID therapy. Furthermore, the severity of dyspeptic symptoms appears worsein infected drug users. Both Chemical and Helicobacter gastritis, by increasing neutrophils in the tissue, lead to ulcers, although the induction of prostaglandin synthesis by inflammation in some circumstances may also be mildly protective. More ulcers are found in Hp+ve than Hp-ve users of NSAIDS, but ulcers in the stomach may heal more easily with acid suppressive therapy in infected patients. Eradication of infection is beneficial in aspirinusers and in those beginning NANSAID therapy. Adaptation to aspirin is confined to Hp-ve cases. However, in long-term users of NANSAIDs, H. pylori eradication does not appear to speed ulcer healing, reduce recurrence, or prevent complications. These are best achieved by long-term maintenance therapy with a proton-pump inhibitor drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:59:27