Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis and tritium labeling of new aromatic diazirine building blocks for photoaffinity labeling and cross-linking
Autore:
Ambroise, Y; Pillon, F; Mioskowski, C; Valleix, A; Bernard, B;
Indirizzi:
CEA Saclay, Serv Mol Marquees, F-91191 Gif Sur Yvette, France CEA Saclay Gif Sur Yvette France F-91191 F-91191 Gif Sur Yvette, France
Titolo Testata:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
fascicolo: 20, , anno: 2001,
pagine: 3961 - 3964
SICI:
1434-193X(200110):20<3961:SATLON>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH SPECIFIC RADIOACTIVITY; PHOSPHOLIPIDIC PROBE; AFFINITY; SELECTIVITY; RECEPTORS; PROTEINS; ANALOG;
Keywords:
diazirine; hydrogenations; isotopic labeling; photoaffinity labeling; tritium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bernard, B CEA Saclay, Serv Mol Marquees, F-91191 Gif Sur Yvette, France CEA Saclay Gif Sur Yvette France F-91191 f Sur Yvette, France
Citazione:
Y. Ambroise et al., "Synthesis and tritium labeling of new aromatic diazirine building blocks for photoaffinity labeling and cross-linking", EUR J ORG C, (20), 2001, pp. 3961-3964

Abstract

The synthesis of three bifunctional 3-phenyl-3-(trifluoromethyl)diazirinylbuilding blocks is described. These compounds were designed for their potential chemical reactivity toward a wide range of functional groups occurring in proteins and small molecules. Moreover, we also synthesized the tritiated versions of these three building blocks, using a recently reported chemoselective and regiospecific key-reaction. These building blocks represent a new family of radiolabeled molecules that can be utilized as photoactivatable tags for labeling of proteins or small molecules by using crosslinkingor site-directed photoaffinity labeling techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:14:58