Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Short-term fish oil supplementation improved innate immunity, but increased ex vivo oxidation of LDL in man - a pilot study
Autore:
Turini, ME; Crozier, GL; Donnet-Hughes, A; Richelle, MA;
Indirizzi:
Nestec Ltd, Nestle Res Ctr, Dept Nutr, CH-1000 Lausanne 26, Switzerland Nestec Ltd Lausanne Switzerland 26 utr, CH-1000 Lausanne 26, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF NUTRITION
fascicolo: 2, volume: 40, anno: 2001,
pagine: 56 - 65
SICI:
1436-6207(200104)40:2<56:SFOSII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; PERFORMANCE LIQUID-CHROMATOGRAPHY; RED-BLOOD-CELLS; VITAMIN-E; LIPID-PEROXIDATION; SALMONELLA-TYPHIMURIUM; KUPFFER CELL; FATTY-ACIDS; OLEATE-RICH; PLASMA;
Keywords:
fish oil; high-oleic acid oil; immune; lipoproteins; phagocytosis; respiratory burst; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Turini, ME Nestec Ltd, Nestle Res Ctr, Dept Nutr, POB 44, CH-1000 Lausanne26, Switzerland Nestec Ltd POB 44 Lausanne Switzerland 26 anne 26, Switzerland
Citazione:
M.E. Turini et al., "Short-term fish oil supplementation improved innate immunity, but increased ex vivo oxidation of LDL in man - a pilot study", EUR J NUTR, 40(2), 2001, pp. 56-65

Abstract

Background. Fish and fish oils are rich. in the two, long. chain polyunsaturated fatty acids (LCPUFAs) eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3). The n-3 LCPUFAs have been reported to have beneficial effects, on cardiovascular functions, but their role in relationto immune functions is still controversial. Aim of the study: The objectives of this study were to determine the effects of supplementation with fishoil on immune cell functions in human subjects., We have also assessed theeffects on plasma lipids, antioxidant status, and susceptibility of low-density lipoproteins (LDL) to oxidative stress., The antioxidant status was determined by measuring plasma vitamin C, tocopherols and carotenoids in plasma and LDL, and superoxide dismutase (SOD) in red blood cells. Design: For30, days, 10, volunteers ingested 25 g/d of either fish oil, providing n-3LCPUFAs, (7.5 g),. or high-oleic sunflower oil, providing monounsaturated fatty acids mainly as oleic add (22 g). The oils, contained similar profiles, of tocopherols. At day 0 and day 30, blood samples were drawn by venipuncture for plasma lipid and antioxidant analyses and lipoprotein isolation, and for isolation and functional tests of mononuclear cells and granulocytes. Fatty acid profiles of immune cells and LDL were also determined. Results. Fish oil supplementation resulted in an accumulation of n-3 LCPUFAs (EPA, DHA); in LDL and immune cells. The, phagocytic activity, a measure of immune cell activity, was increased in both groups. Whereas the plasma and LDLandoxidant status, do not appear to be affected by fish oil supplementation, an increased susceptibility of LDL to oxidation was observed in these healthy volunteers. Conclusions. The optimal amounts of n-3 fatty acids, required to modulate immune functions remain to be established. In addition, adequate levels of antioxidant protection need to be provided during fish oilsupplementation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:46:46