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Titolo:
Caspase inhibitors increase short-term survival of progenitor-cell progenyin the adult rat dentate gyrus following status epilepticus
Autore:
Ekdahl, CT; Mohapel, P; Elmer, E; Lindvall, O;
Indirizzi:
Wallenberg Neurosci Ctr, Sect Restorat Neurol, SE-22184 Lund, Sweden Wallenberg Neurosci Ctr Lund Sweden SE-22184 urol, SE-22184 Lund, Sweden Wallenberg Neurosci Ctr, Sect Expt Brain Res, SE-22184 Lund, Sweden Wallenberg Neurosci Ctr Lund Sweden SE-22184 Res, SE-22184 Lund, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 6, volume: 14, anno: 2001,
pagine: 937 - 945
SICI:
0953-816X(200109)14:6<937:CIISSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ACTIVATION; DNA FRAGMENTATION; LIMBIC SEIZURES; HIPPOCAMPAL-NEURONS; INCREASED NEUROGENESIS; ADRENAL-STEROIDS; EXCITATORY INPUT; GRANULE CELLS; FLUORO-JADE; DEATH;
Keywords:
apoptosis; cysteinyl aspartate-specific proteinases; epilepsy; neurogenesis; pilocarpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Lindvall, O Wallenberg Neurosci Ctr, Sect Restorat Neurol, BMC A11, SE-22184 Lund, Sweden Wallenberg Neurosci Ctr BMC A11 Lund Sweden SE-22184 , Sweden
Citazione:
C.T. Ekdahl et al., "Caspase inhibitors increase short-term survival of progenitor-cell progenyin the adult rat dentate gyrus following status epilepticus", EUR J NEURO, 14(6), 2001, pp. 937-945

Abstract

The dentate gyrus (DG) is one of the few regions in the brain that continues to produce new neurons throughout adulthood. Seizures not only increase neurogenesis, but also lead to death of DG neurons. We investigated the relationship between cell death and neurogenesis following seizures in the DG of adult rats by blocking caspases, which are key components of apoptotic cell death. Multiple intracerebroventricular infusions of caspase inhibitors(pancaspase inhibitor zVADfmk, and caspase 3 and 9 inhibitor) prior to, just after, 1 day after, and 1 week following 2 h of lithium-pilocarpine-induced status epilepticus reduced the number of terminal deoxynucleotidyl transferase-mediated fluorescein-dUTP nick-end labelled (TUNEL) cells and increased the number of bromodeoxyuridine (BrdU)-stained proliferated cells in the subgranular zone at 1 week. The caspase inhibitor-treated group did not differ from control at 2 days or 5 weeks following the epileptic insult. Our findings suggest that caspases modulate seizure-induced neurogenesis in the DG, probably by regulating apoptosis of newly born neurons, and that this action can be suppressed transiently by caspase inhibitors. Furthermore, although previous studies have indicated that increased neuronal death can trigger neurogenesis, we show here that reduction in apoptotic death may beassociated with increased neurogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:20:03