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Titolo:
Stressor categorization: acute physical and psychological stressors elicitdistinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
Autore:
Dayas, CV; Buller, KM; Crane, JW; Xu, J; Day, TA;
Indirizzi:
Univ Queensland, Dept Physiol & Pharmacol, Sch Biomed Sci, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 Brisbane, Qld 4072, Australia
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 14, anno: 2001,
pagine: 1143 - 1152
SICI:
0953-816X(200110)14:7<1143:SCAPAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL AXIS; C-FOS EXPRESSION; PARAVENTRICULAR NUCLEUS; BRAIN-STEM; SYSTEMIC INTERLEUKIN-1-BETA; NEUROENDOCRINE RESPONSES; MESSENGER-RNA; RAT-BRAIN; NEURONS;
Keywords:
forced swim; haemorrhage; hypothalamic-pituitary-adrenal axis; immune challenge; noise; rat; restraint;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Dayas, CV Univ Queensland, Dept Physiol & Pharmacol, Sch Biomed Sci, Brisbane, Qld 4072, Australia Univ Queensland Brisbane Qld Australia 4072 Qld 4072, Australia
Citazione:
C.V. Dayas et al., "Stressor categorization: acute physical and psychological stressors elicitdistinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups", EUR J NEURO, 14(7), 2001, pp. 1143-1152

Abstract

It has been hypothesized that the brain categorizes stressors and utilizesneural response pathways that vary in accordance with the assigned category. If this is true, stressors should elicit patterns of neuronal activationwithin the brain that are category-specific. Data from previous Immediate-early gene expression mapping studies have hinted that this is the case, but interstudy differences in methodology render conclusions tenuous. In the present study, immunolabelling for the expression of c-fos was used as a marker of neuronal activity elicited in the rat brain by haemorrhage, immune challenge, noise, restraint and forced swim. All stressors elicited c-fos expression in 25-30% of hypothalamic paraventricular nucleus corticotrophin-releasing-factor cells, suggesting that these stimuli were of comparable strength, at least with regard to their ability to activate the hypothalamic-pituitary-ad renal axis. In the amygdala, haemorrhage and immune challenge both elicited c-fos expression in a large number of neurons in the central nucleus of the amygdala, whereas noise, restraint and forced swim primarilyelicited recruitment of cells within the medial nucleus of the amygdala. In the medulla, all stressors recruited similar numbers of noradrenergic (A1and A2) and adrenergic (C1 and C2) cells. However, haemorrhage and immune challenge elicited c-fos expression In subpopulations of A1 and A2 noradrenergic cells that were significantly more rostral than those recruited by noise, restraint or forced swim. The present data support the suggestion thatthe brain recognizes at least two major categories of stressor, which we have referred to as 'physical' and 'psychological'. Moreover, the present data suggest that the neural activation footprint that is left in the brain by stressors can be used to determine the category to which they have been assigned by the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:12:19