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Titolo:
Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians
Autore:
Rose, G; Passarino, G; Carrieri, G; Altomare, K; Greco, V; Bertolini, S; Bonafe, M; Franceschi, C; De Benedictis, G;
Indirizzi:
Univ Calabria, Dept Cell Biol, I-87030 Arcavacata Di Rende, Italy Univ Calabria Arcavacata Di Rende Italy I-87030 cavacata Di Rende, Italy Univ Genoa, Dept Internal Med, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Dept Internal Med, Genoa, Italy Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 t Expt Pathol, I-40126 Bologna, Italy Natl Inst Aging Res, Ancona, Italy Natl Inst Aging Res Ancona ItalyNatl Inst Aging Res, Ancona, Italy
Titolo Testata:
EUROPEAN JOURNAL OF HUMAN GENETICS
fascicolo: 9, volume: 9, anno: 2001,
pagine: 701 - 707
SICI:
1018-4813(200109)9:9<701:PILSAO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY OPTIC NEUROPATHY; HUMAN MITOCHONDRIAL-DNA; COMPLEX-I; LIFE-SPAN; DISEASE; VARIANTS; GENOME; MUTATION; GENES; MOUSE;
Keywords:
aging; longevity; mitochondrial DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: De Benedictis, G Univ Calabria, Dept Cell Biol, I-87030 Arcavacata Di Rende, Italy Univ Calabria Arcavacata Di Rende Italy I-87030 , Italy
Citazione:
G. Rose et al., "Paradoxes in longevity: sequence analysis of mtDNA haplogroup J in centenarians", EUR J HUM G, 9(9), 2001, pp. 701-707

Abstract

Previous studies have shown that mitochondrial DNA (mtDNA) haplogroup J issignificantly over-represented in healthy centenarians with respect to younger controls, thus suggesting that this haplogroup predisposes to successful aging and longevity. On the other hand, the same haplogroup is reported to have elevated frequency in some complex diseases. To verify if centenarians clustered in a particular lineage within J we have sequenced the D-loopregion from 18 centenarians and 18 younger controls, previously characterized to be J. Then the entire mtDNA molecule was sequenced in a sub-sample of nine centenarians to find possible functional mutations associated with haplogroup J in successful aging. No clustering of the J haplogroup mtDNA from centenarians was observed. In addition, most of the mutations found are known as disease-associated mutations. The general picture that emerges from the study is that the J haplogroup of centenarians is surprisingly similar to that found in complex diseases, as well as in Leber Hereditary Optic Neuropathy. This finding implies that the same mutations could predispose todisease or longevity, probably according to individual-specific genetic backgrounds and stochastic events. This data reveals another paradox of centenarians and confirms the complexity of the longevity trait.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:37:56