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Titolo:
PAH-DNA adducts in a petrol refinery in Egypt
Autore:
Abdel-Rahman, AG; Allam, MF; Mansour, MT; Mustafa, MAA;
Indirizzi:
Suez Canal Univ, Fac Med, Dept Community & Occupat Med, Isamilia, Egypt Suez Canal Univ Isamilia Egypt Community & Occupat Med, Isamilia, Egypt Univ Cordoba, Fac Med, Dept Prevent Med & Publ Hlth, Cordoba, Spain Univ Cordoba Cordoba Spain Dept Prevent Med & Publ Hlth, Cordoba, Spain Cairo Univ, Natl Canc Inst, Dept Virol & Immunol, Cairo, Egypt Cairo UnivCairo Egypt tl Canc Inst, Dept Virol & Immunol, Cairo, Egypt
Titolo Testata:
EUROPEAN JOURNAL OF CANCER PREVENTION
fascicolo: 5, volume: 10, anno: 2001,
pagine: 469 - 472
SICI:
0959-8278(200110)10:5<469:PAIAPR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHITE BLOOD-CELLS; COKE-OVEN WORKERS; GENETIC-POLYMORPHISM; GENOTYPES; HUMANS; GSTM1; RISK; LYMPHOCYTES; BIOMARKERS; EXPOSURE;
Keywords:
DNA adducts; GSTM1; polycyclic aromatic hydrocarbons; smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Abdel-Rahman, AG Suez Canal Univ, Fac Med, Dept Community & Occupat Med, Isamilia, Egypt Suez Canal Univ Isamilia Egypt at Med, Isamilia, Egypt
Citazione:
A.G. Abdel-Rahman et al., "PAH-DNA adducts in a petrol refinery in Egypt", EUR J CAN P, 10(5), 2001, pp. 469-472

Abstract

Epidemiological surveys in occupationally exposed populations postulate that long-term exposure to polycyclic aromatic hydrocarbons (PAHs) is carcinogenic. We studied the ability of PAHs to induce the formation of adducts inthe DNA of white blood cells of petrol refinery workers exposed at the workplace. Our study included a random sample of 56 workers exposed to PAHs and 37 non-exposed workers. In the univariate analysis, the DNA adduct level of PAH-exposed workers (42.22 +/- 45.11) was significantly increased (P < 0.05) compared with that in the non-exposed group (20.90 +/- 22.56). However, we could not identify either current smoking or absence of glutathione S-transferase class Mu as possible risk factors for DNA adducts. Linear regression analysis identified degree of exposure to PAHs as the only DNA adducts risk factor. Further research with a larger sample size is under investigation to identify the DNA adduct levels and relationship between the different types of PAHs. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 02/04/20 alle ore 05:25:32