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Titolo:
Tomato (Lycopersicon esculentum) allergens in pollen-allergic patients
Autore:
Foetisch, K; Son, DY; Altmann, F; Aulepp, H; Conti, A; Haustein, D; Vieths, S;
Indirizzi:
Paul Ehrlich Inst, Dept Allergol, D-6070 Langen, Germany Paul Ehrlich Inst Langen Germany D-6070 Allergol, D-6070 Langen, Germany Sungkyunkwan Univ, Sch Med, Seoul, South Korea Sungkyunkwan Univ Seoul South Korea n Univ, Sch Med, Seoul, South Korea Agr Univ Vienna, A-1180 Vienna, Austria Agr Univ Vienna Vienna Austria A-1180 niv Vienna, A-1180 Vienna, Austria Borkum Riff Hosp, Borkum, Germany Borkum Riff Hosp Borkum GermanyBorkum Riff Hosp, Borkum, Germany CNR, Colleretto Giacosa, Italy CNR Colleretto Giacosa ItalyCNR, Colleretto Giacosa, Italy
Titolo Testata:
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
fascicolo: 4-5, volume: 213, anno: 2001,
pagine: 259 - 266
SICI:
1438-2377(200110)213:4-5<259:T(EAIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND MAJOR ALLERGEN; N-LINKED OLIGOSACCHARIDES; GRASS-POLLEN; CDNA CLONING; CARBOHYDRATE DETERMINANTS; CROSS-REACTIVITY; CEDAR POLLEN; IDENTIFICATION; PROFILIN; FRUIT;
Keywords:
tomato; food allergy; profilin; carbohydrate epitopes; IgE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vieths, S Paul Ehrlich Inst, Dept Allergol, D-6070 Langen, Germany Paul Ehrlich Inst Langen Germany D-6070 D-6070 Langen, Germany
Citazione:
K. Foetisch et al., "Tomato (Lycopersicon esculentum) allergens in pollen-allergic patients", EUR FOOD RE, 213(4-5), 2001, pp. 259-266

Abstract

This study was undertaken to investigate the relevance of tomato allergy in pollen-allergic patients, and to identify and characterize tomato allergens. Therefore, sera of a group of 32 pollen-allergic patients with a history of adverse reactions to tomato were investigated by means of immunoblotting and specific IgE measurements (CAP, EAST, EAST inhibition and CCD [crossreactive carbohydrate determinants]-ELISA). IgE-reactive spots on 2D blots were analyzed by amino acid microsequencing. Tomato allergy was found to occur with a prevalence of about 9% in our group of birch pollen-allergic patients. Of the patients with adverse reactions to tomato, 44% presented I-E to tomato profilin and 35.5% specific IgE toCCD. Two patients were sensitized to a lipid transfer protein in tomato. Microsequencing of other IgE-reactive proteins, separated by 2D-gel electrophoresis and transferred to PVDF membranes, revealed beta -fructofuranosidase, polygalacturonase 2A, and pectinesterase as further tomato allergens. Our data show that tomato is a relevant allergenic food in pollen-allergic patients. It seems that the majority of pollen-associated allergies to tomatois caused by known ubiquitous allergenic structures such as profilin and cross-reactive IgE-binding N-glycans. Furthermore, lipid transfer protein, as well as polygalacturonase 2A, pectinesterase and beta -fructofuranosidasemay represent birch pollen-independent tomato allergens for certain patients.

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Documento generato il 21/09/20 alle ore 13:45:36