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Titolo:
A meta-analysis of cohort studies describing mortality and cancer incidence among chemical workers in the United States and western Europe
Autore:
Greenberg, RS; Mandel, JS; Pastides, H; Britton, NL; Rudenko, L; Starr, TB;
Indirizzi:
Univ S Carolina, Sch Publ Hlth, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 h Publ Hlth, Columbia, SC 29208 USA TBS Associates, Raleigh, NC USA TBS Associates Raleigh NC USATBS Associates, Raleigh, NC USA Integrat Biostrategies LLC, Washington, DC USA Integrat Biostrategies LLCWashington DC USA ies LLC, Washington, DC USA Med Univ S Carolina, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 ina, Charleston, SC 29425 USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 6, volume: 12, anno: 2001,
pagine: 727 - 740
SICI:
1044-3983(200111)12:6<727:AMOCSD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYURETHANE FOAM INDUSTRY; ETHYLENE-OXIDE WORKERS; FOLLOW-UP; RETROSPECTIVE-COHORT; RUBBER WORKERS; BLADDER-CANCER; LUNG-CANCER; OCCUPATIONAL EXPOSURE; MANUFACTURING PLANT; METHYLENE-CHLORIDE;
Keywords:
chemical industry; worker health; cancer incidence; mortality; occupational exposures; bladder neoplasms; lower respiratory tract neoplasms; lymphohematopoietic neoplasms;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
185
Recensione:
Indirizzi per estratti:
Indirizzo: Pastides, H Univ S Carolina, Sch Publ Hlth, 109 Hlth Sci Bldg,Bldg 76, Columbia, SC 29208 USA Univ S Carolina 109 Hlth Sci Bldg,Bldg 76 Columbia SC USA 29208
Citazione:
R.S. Greenberg et al., "A meta-analysis of cohort studies describing mortality and cancer incidence among chemical workers in the United States and western Europe", EPIDEMIOLOG, 12(6), 2001, pp. 727-740

Abstract

We evaluated the mortality and cancer experience of employees of the chemical industry in the United States and western Europe, as reported in the peer-reviewed literature between 1966 and 1997 (>1 million workers and > 15 million person-years). Cohort studies (N = 461) were grouped (N = 181) so that specific populations could be traced from the earliest to the most recently published report, and we extracted observed and expected numbers of cases for each of 35 mortality and 23 cancer incidence endpoints. We then generated standardized mortality ratios or standardized incidence ratios and 95% confidence intervals, and undertook meta-analyses of subcohorts (for example, gender, latency, or duration of employment), as well as the entire cohort. With few exceptions, the observed cause-specific mortality and site-specific cancer incidences were reassuring: overall, 10% fewer deaths were observed than expected. Fewer than expected deaths from all causes, cardiovascular disease, noncancer respiratory disease, cirrhosis of the liver, and external causes were observed, some or all of which may be attributed to a "healthy worker effect. " Meta-analyses revealed weak to moderate excesses oflung and bladder cancers likely caused by occupational exposure to known human carcinogens. We also observed a 10-15% increase in lymphatic and hematopoietic cancers. Additional research is required to gain a more complete understanding of the potential role that methodology and environmental or occupational influences may play in these associations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:24:53