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Titolo:
Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans
Autore:
Hendricks, KA; Nuno, OM; Suarez, L; Larsen, R;
Indirizzi:
Texas Dept Hlth, Div Infect Dis Epidemiol & Surveillance, Austin, TX 78756USA Texas Dept Hlth Austin TX USA 78756 l & Surveillance, Austin, TX 78756USA Off Associate Commissioner Dis Control & Prevent, Austin, TX USA Off Associate Commissioner Dis Control & Prevent Austin TX USA n, TX USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 6, volume: 12, anno: 2001,
pagine: 630 - 635
SICI:
1044-3983(200111)12:6<630:EOHAOO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; GLYCEMIC CONTROL; INSULIN THERAPY; FETAL GROWTH; WOMEN; PREVENTION; EXPRESSION; PREGNANCY; INFANTS; MOTHERS;
Keywords:
neural tube defects; obesity; diabetes mellitus; birth defects; hyperinsulinemia; Mexican Americans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Hendricks, KA Texas Dept Hlth, Div Infect Dis Epidemiol & Surveillance, 1100 W 49th St, Austin, TX 78756 USA Texas Dept Hlth 1100 W 49th St Austin TXUSA 78756 78756 USA
Citazione:
K.A. Hendricks et al., "Effects of hyperinsulinemia and obesity on risk of neural tube defects among Mexican Americans", EPIDEMIOLOG, 12(6), 2001, pp. 630-635

Abstract

Although both maternal obesity and diabetes mellitus increase the risk forneural tube defects, it is unknown whether they are independent risk factors or manifestations of an underlying prediabetic state such as hyperinsulinemia. We investigated whether hyperinsulinemia was a risk factor for neural tube defects independent of obesity and hyperglycemia in Mexican-Americanwomen. We identified case and control women from residents delivering or terminating pregnancies in hospitals or birthing centers in any of the 14 Texas-Mexico border counties during 1995-2000. Case women had a pregnancy affected by anencephaly, spina bifida, or encephalocele; randomly selected control women had normal births, frequency matched by year and birth facility. Questionnaire and laboratory values obtained 5-6 weeks postpartum were available for 149 case and 178 control women. Both hyperinsulinemia and obesity were related to increased neural tube defect risk [odds ratio (OR) = 1.91, 95% confidence interval (Cl) = 1.21-3.01 and OR = 1.73, 95% Cl = 1.03-2.92, respectively]. Adjustment for obesity only slightly reduced the effect of hyperinsulinemia (OR = 1.75, 95% Cl = 1.09-2.82). Alternatively, a modesteffect remained for obesity after adjustment for hyperinsulinemia (OR = 1.45, 95% Cl = 0.84-2.51). Hyperinsulinemia is a strong risk factor for neural tube defects and may be the driving force for the observed risk in obese women.

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Documento generato il 20/09/20 alle ore 00:32:49