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Titolo:
Effect of voluntary wheel-running on insulin sensitivity and responsiveness in high-fat-fed rats
Autore:
Han, YQ; Oshida, Y; Li, L; Koshinaka, K; Fuku, N; Yamanouchi, K; Sato, Y;
Indirizzi:
Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Chikusa Ku, Nagoya, Aichi4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 sa Ku, Nagoya, Aichi4648601, Japan Nagoya Univ, Grad Sch Med, Dept Sports Med, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 Med, Nagoya, Aichi 4648601, Japan Aichi Med Univ, Dept Internal Med 1, Nagakute, Aichi 4801195, Japan Aichi Med Univ Nagakute Aichi Japan 4801195 agakute, Aichi 4801195, Japan
Titolo Testata:
ENDOCRINE JOURNAL
fascicolo: 5, volume: 48, anno: 2001,
pagine: 551 - 555
SICI:
0918-8959(200110)48:5<551:EOVWOI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-UTILIZATION; RESISTANCE; MUSCLE; EXERCISE; DIET; MECHANISMS; METABOLISM; TRANSPORT; DISEASE; NIDDM;
Keywords:
euglycemic clamp technique; insulin resistance; voluntary running; high-fat diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Oshida, Y Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan Nagoya Univ Furo Cho Nagoya Aichi Japan4648601 i 4648601, Japan
Citazione:
Y.Q. Han et al., "Effect of voluntary wheel-running on insulin sensitivity and responsiveness in high-fat-fed rats", ENDOCR J, 48(5), 2001, pp. 551-555

Abstract

The effect of voluntary wheel-running on insulin resistance was studied inhigh-fat-fed rats. A sequential hyperinsulinemic euglycemic clamp procedure was employed (insulin infusion rates: 3 and 30 mU/kg BW/min) in 14 high-fat-fed rats and 7 chow-fed rats under the awake condition. The high-fat-fedrats were further divided into a sedentary (n=7) and a voluntary wheel-running (n=7) groups. Blood glucose was clamped at the fasting level in each rat. Plasma insulin levels during the 3- and 30-mU/kg BW/min insulin infusions were 40-50 and 450-550, muU/ml, respectively. At both 3 and 30 mU/kg BW/min insulin infusions, high-fat-feeding showed a significant decrease in glucose infusion rate (GIR), compared with the chow-fed rats. However, decreased GIRs were restored by the 4-wk wheel-running and reached similar levelsas the chow-fed rats. Therefore, it could be concluded that voluntary wheel-running prevents insulin resistance induced by high-fat feeding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:21:42