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Titolo:
Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE
Autore:
Crozet, C; Bencsik, A; Flamant, F; Lezmi, S; Samarut, J; Baron, T;
Indirizzi:
Agence Francaise Secur Sanitaire Aliments, Unite Virol ATNC, F-69364 Lyon,France Agence Francaise Secur Sanitaire Aliments Lyon France F-69364 yon,France Ecole Normale Super, Lab Biol Mol & Cellulaire, Lyon, France Ecole NormaleSuper Lyon France Lab Biol Mol & Cellulaire, Lyon, France
Titolo Testata:
EMBO REPORTS
fascicolo: 10, volume: 2, anno: 2001,
pagine: 952 - 956
SICI:
1469-221X(200110)2:10<952:FPIOPT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE SPONGIFORM ENCEPHALOPATHY; CREUTZFELDT-JAKOB-DISEASE; PRION PROTEIN; MOLECULAR ANALYSIS; STRAIN VARIATION; VARIANT CJD; SCRAPIE; TRANSMISSION; SHEEP; AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Crozet, C Agence Francaise Secur Sanitaire Aliments, Unite Virol ATNC, 31 Ave Tony Garnier, F-69364 Lyon, France Agence Francaise Secur Sanitaire Aliments 31 Ave Tony Garnier Lyon France F-69364
Citazione:
C. Crozet et al., "Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE", EMBO REP, 2(10), 2001, pp. 952-956

Abstract

The occurrence of the variant Creutzfeldt-Jakob disease (vCJD), related tobovine spongiform encephalopathy (BSE), raises the important question of the sources of human contamination. The possibility that sheep may have beenfed with BSE-contaminated foodstuff raises the serious concern that BSE may now be present in sheep without being distinguishable from scrapie. Sensitive models are urgently needed given the dramatic consequences of such a possible contamination on animal and human health. We inoculated transgenic mice expressing the ovine PrP gene with a brain homogenate from sheep experimentally infected with BSE. We found numerous typical florid plaques in their brains. Such florid plaques are a feature of vCJD in humans and experimental BSE infection in macaques. Our observation represents the first description, after a primary infection, of this hallmark in a transgenic mouse model. Moreover, these mice appear to be a promising tool in the search for BSE in sheep.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:47:39