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Titolo:
Brinker requires two co repressors for maximal and versatile repression inDpp signalling
Autore:
Hasson, P; Muller, B; Basler, K; Paroush, Z;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, IL-91120 Jerusalem,Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 L-91120 Jerusalem,Israel Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 Biol, CH-8057 Zurich, Switzerland
Titolo Testata:
EMBO JOURNAL
fascicolo: 20, volume: 20, anno: 2001,
pagine: 5725 - 5736
SICI:
0261-4189(20011015)20:20<5725:BRTCRF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL REPRESSION; DROSOPHILA EMBRYO; MORPHOGEN GRADIENT; RANGE REPRESSION; GROUCHO; PROTEINS; EXPRESSION; HAIRY; KNIRPS; GENE;
Keywords:
Brinker; CtBP; Dpp signalling; Groucho; transcriptional repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Paroush, Z Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Biochem, POB 12272, IL-91120Jerusalem, Israel Hebrew Univ Jerusalem POB 12272 Jerusalem Israel IL-91120 rael
Citazione:
P. Hasson et al., "Brinker requires two co repressors for maximal and versatile repression inDpp signalling", EMBO J, 20(20), 2001, pp. 5725-5736

Abstract

decapentaplegic (dpp) encodes a Drosophila transforming growth factor-betahomologue that functions as a morphogen in the developing embryo and in adult appendage formation. In the wing imaginal disc, a Dpp gradient governs patterning along the anteroposterior axis by inducing regional expression of diverse genes in a concentration-dependent manner. Recent studies show that responses to graded Dpp activity also require an input from a complementary and opposing gradient of Brinker (Brk), a transcriptional repressor protein encoded by a Dpp target gene. Here we show that Brk harbours a functional and transferable repression domain, through which it recruits the corepressors Groucho and CtBP. By analysing transcriptional outcomes arising from the genetic removal of these corepressors, and by ectopically expressing Brk variants in the embryo, we demonstrate that these corepressors are alternatively used by Brk for repressing some Dpp-responsive genes, whereas forrepressing other distinct target genes they are not required. Our results show that Brk utilizes multiple means to repress its endogenous target genes, allowing repression of a multitude of complex Dpp target promoters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:29:16