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Titolo:
Micellar electrokinetic chromatography of tri aza aromatic ligand compounds of iron (II): Influence of bile salt type on enantiomeric separation
Autore:
Elshihabi, S; Black, KD; Sutton, JK; Woody, KA; Burke, JA; Bushey, MM;
Indirizzi:
Trinity Univ, Dept Chem, San Antonio, TX 78212 USA Trinity Univ San Antonio TX USA 78212 ept Chem, San Antonio, TX 78212 USA
Titolo Testata:
ELECTROPHORESIS
fascicolo: 17, volume: 22, anno: 2001,
pagine: 3771 - 3777
SICI:
0173-0835(200110)22:17<3771:MECOTA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-ZONE-ELECTROPHORESIS; BILIRUBIN-IX-ALPHA; CHIRAL SEPARATION; SODIUM CHOLATE; INTERACTION COMPLEXES; CRYSTAL-STRUCTURE; ORGANIC-SOLVENT; MIXED MICELLES; TAURODEOXYCHOLATE; TAUROCHOLATE;
Keywords:
micellar electrokinetic chromatography; bile salts; metal-ligand complexes; chiral separations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bushey, MM Trinity Univ, Dept Chem, 715 Stadium Dr, San Antonio, TX 78212 USA Trinity Univ 715 Stadium Dr San Antonio TX USA 78212 78212 USA
Citazione:
S. Elshihabi et al., "Micellar electrokinetic chromatography of tri aza aromatic ligand compounds of iron (II): Influence of bile salt type on enantiomeric separation", ELECTROPHOR, 22(17), 2001, pp. 3771-3777

Abstract

Micellar electrokinetic chromatography is used with a variety of bile saltmicelles to separate the enantiomers of bis(8-((pyridine-2-methylene)amino)quinoline)iron(Il) hexafluorophosphate, Fe(PMAQ)(2)(PF6)(2); bis(8-((pyridine-2-methylene)amino)lepidine iron(Il) hexafluorophosphate, Fe(PMAL)(2)(PF6)(2); and bis(1-(2-pyridinyl)ethylidine)-8-aminoquinoline iron(Il) hexafluorophosphate, Fe(PEAQ)(2)(PF6)(2). The influence of ten different bile salts on the resolution of each pair of enantiomers is investigated. Significant changes in resolution are seen depending upon the bile salt used. The dihydroxy bile salts are superior to the trihydroxy bile salts in terms of resolution, and the taurine or glycine conjugated bile salts yield better results than the unconjugated bile salts. Resolution for most enantiomers is maximized in a buffer solution containing 10-15% acetone and employing eithertaurochenodeoxycholic or glycochenodeoxycholic acid as the bile salt. Evidence for the separation of the corresponding Fe(III) complexes is presented.

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Documento generato il 16/07/20 alle ore 06:43:40