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Titolo:
P2 receptors on macroglial cells: Functional implications for gliosis
Autore:
Franke, H; Bringmann, A; Pannicke, T; Krugel, U; Grosche, J; Reichenbach, A; Illes, P;
Indirizzi:
Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, D-04107 Leipzig, Germany Univ Leipzig Leipzig Germany D-04107 & Toxikol, D-04107 Leipzig, Germany Univ Leipzig, Paul Flechsig Inst Brain Res, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 t Brain Res, D-7010 Leipzig, Germany
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 2-3, volume: 53, anno: 2001,
pagine: 140 - 147
SICI:
0272-4391(200106/07)53:2-3<140:PROMCF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL SPINAL-CORD; FIBROBLAST GROWTH-FACTOR; EXTRACELLULAR ATP; PURINERGIC RECEPTORS; MULLER CELLS; REACTIVE ASTROGLIOSIS; INTRACELLULAR CALCIUM; NUCLEOTIDE RECEPTOR; P-2 PURINOCEPTORS; P2X(7) RECEPTORS;
Keywords:
astrocytes; Muller glial cells; P2 receptors; reactive astrogliosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Illes, P Univ Leipzig, Rudolf Boehm Inst Pharmakol & Toxikol, Hartelstr 16-18, D-04107 Leipzig, Germany Univ Leipzig Hartelstr 16-18 Leipzig GermanyD-04107 ig, Germany
Citazione:
H. Franke et al., "P2 receptors on macroglial cells: Functional implications for gliosis", DRUG DEV R, 53(2-3), 2001, pp. 140-147

Abstract

The present review summarizes data about the expression of P2 receptors intwo types of macroglial cells, i.e., in astrocytes of the nucleus accumbens (NAc) and Moller glial cells of the retina. Changes in the expression of these receptors during pathological conditions may indicate an involvement in the induction and/or maintenance of reactive astrogliosis. In fact, astrocytic proliferation was induced in the NAc by the application of differentP2X and P2Y receptor agonists, such as 2-methylthio ATP (2-MeSATP), alpha,beta -methylene adenosine 5'-triphosphate (alpha,beta -meATP) and adenosine5'-O-(2-thiodiphosphate (ADP-beta -S). An increased content of glial fibrillary acidic protein, astrocytic hypertrophy, and proliferation as indicated by enhanced incorporation of 5-bromo-2'-deoxyuridine (BrdU) was found under these conditions; an enhanced BrdU incorporation signalizes a higher rate of DNA synthesis. Moller glial cells of the human retina express both metabotropic P2Y and ionotropic P2X(7) receptors. Application of the P2X(7) receptor agonist benzoyl-benzoyl ATP (BzATP) evoked a cationic conductance increase that led to the depolarization of cells and to Ca2+ entry from the extracellular space. Long-lasting application of BzATP, however, did not cause the formation of pores permeable for large molecules, excluding the presence of classic P2X(7) receptors. Moller glial cells of the human retina show increased P2X(7) receptor-mediated cationic currents during proliferative gliosis. A role of P2X(7) receptors in glial proliferation is also indicated by the observation that the DNA synthesis rate of cultured Moller cellsis enhanced in the presence of BzATP, as shown by the measurement of BrdU incorporation. The data indicate that activation of P2 receptors may exert both short- and long-term effects in macroglial cells, and that these receptors may be involved in glial responses to pathological conditions. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:25:43