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Titolo:
Dipyrone inhibits ethanol withdrawal and pentylenetetrazol-induced seizures in rats
Autore:
Ergun, H; Uzbay, IT; Celik, T; Kayir, H; Yesilyurt, O; Tulunay, FC;
Indirizzi:
Gulhane Mil Med Acad, Fac Med, Dept Med Pharmacol, Psychopharmacol Res Unit, TR-06018 Ankara, Turkey Gulhane Mil Med Acad Ankara Turkey TR-06018 nit, TR-06018 Ankara, Turkey Ankara Univ, Fac Med, Dept Pharmacol & Clin Pharmacol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 in Pharmacol, TR-06100 Ankara, Turkey
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 4, volume: 53, anno: 2001,
pagine: 254 - 259
SICI:
0272-4391(200108)53:4<254:DIEWAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CENTRAL NERVOUS-SYSTEM; GABA(A) RECEPTORS; BRAIN; ADENOSINE; MECHANISM; ANTICONVULSANT; PROSTAGLANDINS; CONVULSIONS; GLUTAMATE;
Keywords:
dipyrone; seizure; ethanol withdrawal; pentylenetetrazol; rat(s);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Uzbay, IT Gulhane Mil Med Acad, Fac Med, Dept Med Pharmacol, Psychopharmacol Res Unit, TR-06018 Ankara, Turkey Gulhane Mil Med Acad Ankara Turkey TR-06018 018 Ankara, Turkey
Citazione:
H. Ergun et al., "Dipyrone inhibits ethanol withdrawal and pentylenetetrazol-induced seizures in rats", DRUG DEV R, 53(4), 2001, pp. 254-259

Abstract

The effects of dipyrone, a nonnarcotic analgesic drug, on ethanol withdrawal and pentylenetetrazol (PTZ)-induced seizures in male Wistar rats were investigated. Ethanol (7.2%) was given to rats by a liquid diet for 21 days. After 6 h of ethanol withdrawal, rats were exposed to an audiogenic stimulus (100 dB) for 60 sec for induction of seizures. Dipyrone (50, 100, and 200mg/kg ip) and saline were administered to rats 30 min before audiogenic stimulus, and the effects of dipyrone on the seizures induced by audiogenic stimulus were evaluated. The effects of dipyrone on PTZ-induced seizures were also evaluated in other individual groups of the rats. The same doses of dipyrone were injected in the rats ip 30 min before PTZ (50 mg/kg) injections. Immediately after PTZ injections, onset time and severity of the convulsions were recorded. Dipyrone significantly and dose-dependently reduced both incidence and intensity of the ethanol withdrawal-associated audiogenic seizures. It also inhibited significantly and dose-dependently intensity but not onset time of the PTZ-induced seizures. Dipyrone (50-200 mg/kg) did not produce any significant change in locomotor activity in naive rats. Our results suggest that dipyrone has some prominent anticonvulsant activities on both ethanol withdrawal and PTZ-induced seizures in rats, and that usingdipyrone may be a new and effective therapeutic approach in the treatment of seizures. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:34:38