Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prospective study of diabetes mellitus and liver cancer in Japan
Autore:
Fujino, Y; Mizoue, T; Tokui, N; Yoshimura, T;
Indirizzi:
Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Clin Epidemiol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 5, volume: 17, anno: 2001,
pagine: 374 - 379
SICI:
1520-7552(200109/10)17:5<374:PSODMA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-I RECEPTOR; PRIMARY HEPATOCELLULAR-CARCINOMA; HEPATITIS-C VIRUS; RISK-FACTORS; CLINICAL-DIAGNOSIS; POPULATION; GROWTH; APOPTOSIS; METABOLISM; CIRRHOSIS;
Keywords:
cohort studies; diabetes mellitus; liver neoplasms; neoplasms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Fujino, Y Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Clin Epidemiol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 n
Citazione:
Y. Fujino et al., "Prospective study of diabetes mellitus and liver cancer in Japan", DIABET M R, 17(5), 2001, pp. 374-379

Abstract

Background Previous studies have identified the association between diabetes mellitus and liver cancer. However, the detail of this association is still unclear, in terms of confounding factors, the trend according to the duration of diabetes, and the interaction between diseases associated with the liver cancer and this association. The purpose of the present study was to examine the association between diabetes and liver cancer in view of the trend and the interaction. Methods The baseline survey was conducted during the period 1986-1989 among the general population of Fukuoka Prefecture, Japan (15 417 persons, aged30-79 years). The respondents were assessed for history of diabetes, age at which they had had diabetes, and other covariates by means of a baseline questionnaire. A total of 7308 persons aged 40-79 years were retrieved for the main analysis and 4902 persons for a subcohort from which the information on history of diseases associated with liver cancer were obtained. The relative risks (RR) and their 95% confidence intervals (CIs) were estimated using the Cox proportional hazards model. Results After adjustment for smoking, alcohol and the diseases associated with liver cancer, the RR for liver cancer was 2.06 (95% CI = 1.01-4.19). Diabetes increased the risk of liver cancer in persons with hepatitis and/orcirrhosis (RR=2.90, 95% CI=113-7.41). However, the RR of diabetes, for liver cancer was 1.35 (95% CI = 0.41-4.43) in persons without hepatitis and cirrhosis. The trend according to the duration of diabetes was not seen. Conclusions A significant association between diabetes and liver cancer was observed. Moreover, this association was modified by hepatitis and cirrhosis. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:37:31