Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Renal handling of uric acid assessed by means of pharmacological tests in obese women
Autore:
Gonzalez-Ortiz, M; Martinez-Abundis, E; Mora-Martinez, JM; Grover-Paez, F;
Indirizzi:
Mexican Inst Social Secur, W Natl Med Ctr, Med Res Unit Clin Epidemiol, Guadalajara, Jalisco, Mexico Mexican Inst Social Secur Guadalajara Jalisco Mexico ra, Jalisco, Mexico
Titolo Testata:
DIABETES NUTRITION & METABOLISM
fascicolo: 4, volume: 14, anno: 2001,
pagine: 189 - 194
SICI:
0394-3402(200108)14:4<189:RHOUAA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-SUBJECTS; INSULIN; METABOLISM; HYPERURICEMIA; RESISTANCE; EXCRETION; SERUM;
Keywords:
uric acid; renal excretion of uric acid; renal handling of uric acid; obesity; obese women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Ortiz, M Montes Urales 1409,Colonia Independencia, Guadalajara 44340, Jalisco, Mexico Montes Urales 1409,Colonia Independencia Guadalajara Jalisco Mexico 44340
Citazione:
M. Gonzalez-Ortiz et al., "Renal handling of uric acid assessed by means of pharmacological tests in obese women", DIABET NUTR, 14(4), 2001, pp. 189-194

Abstract

The aim of this study was to compare the renal handling of uric acid by means of pyrazinamide and probenecid tests between obese and non-obese women. A cross-sectional study was carried out in 8 obese women and in 8 non-obese women as control group. Metabolic profile and renal handling of uric acidincluding clearance, fractional excretion and excretion rates, were assessed. Due to technical problems, pyrazinamide and probenecid tests were performed only in 5 women of each group to evaluate presecretory reabsorption, secretion and post-secretory reabsorption of uric acid. Uric acid clearance had a tendency to be lower in the obese women than in the control group. There were no significant differences between the groups in fractional excretion and excretion uric acid rates. Pre- and post-secretory reabsorptions ofuric acid did not differ between the obese and the non-obese women. Tubular secretion of uric acid was significantly lower in the obese women compared with the control group (6.4 vs 13.6%; p=0.02). Tubular secretion of uric acid negatively correlated with body mass index (r=-0.73; p <0.05). In conclusion, tubular secretion of uric acid possibly plays an important role in uric acid homeostasis in obese women. (C) 2001, Editrice Kurds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:28:49