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Titolo:
FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia
Autore:
Bermingham-McDonogh, O; Stone, JS; Reh, TA; Rubel, EW;
Indirizzi:
Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 aring Res Ctr, Seattle, WA 98195 USA Univ Washington, Dept Biol Struct, Sch Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ruct, Sch Med, Seattle, WA 98195 USA Univ Washington, Dept Otolaryngol Head & Neck Surg, Sch Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Surg, Sch Med, Seattle, WA 98195 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 238, anno: 2001,
pagine: 247 - 259
SICI:
0012-1606(20011015)238:2<247:FEDDAR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIR-CELL REGENERATION; FIBROBLAST-GROWTH-FACTOR; LIGHT-MICROSCOPIC EVIDENCE; MESSENGER-RNA EXPRESSION; BASILAR PAPILLA; ACOUSTIC TRAUMA; RAT COCHLEA; AMINOGLYCOSIDE OTOTOXICITY; FACTOR-ALPHA; IN-VITRO;
Keywords:
Cek2; basilar papilla; chicken; hair cell; growth factors; receptors; cochlea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Bermingham-McDonogh, O Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Box 357923, Seattle, WA 98195 USA Univ Washington Box 357923 Seattle WA USA 98195 USA
Citazione:
O. Bermingham-McDonogh et al., "FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia", DEVELOP BIO, 238(2), 2001, pp. 247-259

Abstract

Several studies suggest fibroblast growth factor receptor 3 (FGFR3) plays a role in the development of the auditory epithelium in mammals. We undertook a study of FGFR3 in the developing and mature chicken inner ear and during regeneration of this epithelium to determine whether FGFR3 shows a similar pattern of expression in birds. FGFR3 mRNA is highly expressed in most support cells in the mature chick basilar papilla but not in vestibular organs of the chick. The gene is expressed early in the development of the basilar papilla. Gentamicin treatment sufficient to destroy hair cells in the basilar papilla causes a rapid, transient downregulation of FGFR3 mRNA in the region of damage. In the initial stages of hair cell regeneration, the support cells that reenter the mitotic cycle in the basilar papilla do not express detectable levels of FGFR3 mRNA. However, once the hair cells have regenerated in this region, the levels of FGFR3 mRNA and protein expression rapidly return to approximate those in the undamaged epithelium. These results indicate that FGFR3 expression changes after drug-induced hair cell damage to the basilar papilla in an opposite way to that found in the mammaliancochlea and may be involved in regulating the proliferation of support cells. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:49:30