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Titolo:
Ras signaling pathway proteins as therapeutic targets
Autore:
Adjei, AA;
Indirizzi:
Mayo Clin, Div Med Oncol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 , Div Med Oncol, Rochester, MN 55905 USA
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 16, volume: 7, anno: 2001,
pagine: 1581 - 1594
SICI:
1381-6128(200111)7:16<1581:RSPPAT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FARNESYL TRANSFERASE INHIBITORS; NUCLEOTIDE DISSOCIATION STIMULATOR; MAP KINASE KINASE; LUNG-CANCER CELLS; PHASE-I; HA-RAS; INCREASING COMPLEXITY; TRANSFORMING SEQUENCE; DEPENDENT ACTIVATION; MEMBRANE ASSOCIATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Adjei, AA Mayo Clin, Div Med Oncol, 200 1st St Sw, Rochester, MN 55905 USAMayo Clin 200 1st St Sw Rochester MN USA 55905 ter, MN 55905 USA
Citazione:
A.A. Adjei, "Ras signaling pathway proteins as therapeutic targets", CUR PHARM D, 7(16), 2001, pp. 1581-1594

Abstract

Ras is a 21 kDa membrane-localized G protein that is coupled to receptor and non-receptor tyrosine kinase activation of downstream cytoplasmic and nuclear events. Mutated ras genes are common, and occur in a wide variety of human malignancies. These activating mutations result in constitutive signaling, thereby stimulating cell proliferation and inhibiting apoptosis. Preclinically, inhibitors of ras signaling revert ras-dependent cellular transformation, and cause regression of ras-dependent rodent tumor xenografts. The ras signaling pathway has therefore attracted considerable, attention as a target for anticancer therapy. In this review, novel therapeutic approaches based on the inhibition of ras-mediated signaling, are described. The discussion will be limited to inhibitors which are currently in human clinical trials, and include inhibitors of ras processing, inhibitors of ras protein synthesis and inhibitors of downstream ras effectors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:41:02