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Titolo:
New strategy developments in brain tumor therapy
Autore:
Brandes, AA; Basso, U; Pasetto, LM; Ermani, M;
Indirizzi:
Univ Padua, Div Med Oncol, Azienda Osped, Dept Oncol, I-35100 Padua, ItalyUniv Padua Padua Italy I-35100 a Osped, Dept Oncol, I-35100 Padua, Italy Univ Padua, Dept Neurol Sci, Azienda Osped, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 Sci, Azienda Osped, I-35100 Padua, Italy
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 16, volume: 7, anno: 2001,
pagine: 1553 - 1580
SICI:
1381-6128(200111)7:16<1553:NSDIBT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-GRADE GLIOMAS; CENTRAL-NERVOUS-SYSTEM; RECURRENT MALIGNANT GLIOMAS; PHASE-II TRIAL; METHYLGUANINE-DNA METHYLTRANSFERASE; ANTIANGIOGENIC GENE-THERAPY; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE ACTIVITY; MATRIX-METALLOPROTEINASE INHIBITORS; SCHEDULE-DEPENDENT ACTIVITY; HIGH-DOSE TAMOXIFEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
187
Recensione:
Indirizzi per estratti:
Indirizzo: Brandes, AA Univ Padua, Div Med Oncol, Azienda Osped, Dept Oncol, Direz,Via Giustiniani 2, I-35100 Padua, Italy Univ Padua Direz,Via Giustiniani 2 Padua Italy I-35100 Italy
Citazione:
A.A. Brandes et al., "New strategy developments in brain tumor therapy", CUR PHARM D, 7(16), 2001, pp. 1553-1580

Abstract

Background: The incidence of brain and other central nervous system malignant neoplasias is 6.5 cases per 100,000 inhabitants-years, and appears to increase with increasing age (1.2 % per year), with the greatest rate of increase in the population over age 70 years. Material and methods: Chemotherapy remains part of the treatment that includes surgery and radiation therapy for the management of malignant gliomas. This article reviews the new drugs that have been introduced in the treatment of these patients in the latest years, their specific cellular targets, the objective response, the TTP and the MST. Results: The, most encouraging results to date come from studies of temozolomide, which is one of the most active and best tolerated drugs in recent years, and from clinical trials of CPT11. Conclusions: New approaches to chemotherapy treatment are necessary. Enrollment of patients intorigorous, well conducted, clinical trials, both at tumor diagnosis and recurrence, will generate new information regarding investigational therapies,and may offer improved therapies for patients with malignant gliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:47:35