Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The cell biology of Alzheimer's disease: uncovering the secrets of secretases
Autore:
Walter, J; Kaether, C; Steiner, H; Haass, C;
Indirizzi:
Univ Munich, Dept Biochem, Adolf Butenandt Inst, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 sons Dis Res, D-80336 Munich, Germany
Titolo Testata:
CURRENT OPINION IN NEUROBIOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 585 - 590
SICI:
0959-4388(200110)11:5<585:TCBOAD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; BETA-SECRETASE; PRESENILIN-1; CLEAVAGE; NOTCH; IDENTIFICATION; ENDOCYTOSIS; RELEASE; ENZYME; COMPARTMENTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Walter, J Univ Munich, Dept Biochem, Adolf Butenandt Inst, Lab Alzheimers & Parkinsons Dis Res, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 es, D-80336 Munich, Germany
Citazione:
J. Walter et al., "The cell biology of Alzheimer's disease: uncovering the secrets of secretases", CUR OP NEUR, 11(5), 2001, pp. 585-590

Abstract

Progress has been made in characterizing the secretases involved in endoproteolytic processing of the beta -amyloid precursor protein - the precursorof the amyloid beta -peptide (A beta), which is the main constituent of amyloid plaques that form in the brains of patients with Alzheimer's disease. It is now thought that A beta is pivotal in the pathogenesis of Alzheimer's disease, and that reducing brain A beta levels may help to treat or prevent the disease. Two essential factors for the proteolytic generation of A beta have been identified, beta -secretase and the presenilins, which might aid the design of drugs against this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:30:46