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Titolo:
Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens
Autore:
McKenzie, GJ; Rosenberg, SM;
Indirizzi:
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Dept Biochem, Houston, TX 77030 USA Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 l & Microbiol, Houston, TX 77030 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 5, volume: 4, anno: 2001,
pagine: 586 - 594
SICI:
1369-5274(200110)4:5<586:AMMDPA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIONARY-PHASE MUTATION; REVERSIBLE FRAMESHIFT MUTATION; ESCHERICHIA-COLI; TRYPANOSOMA-BRUCEI; ANTIGENIC VARIATION; MISMATCH REPAIR; POINT MUTATIONS; AFRICAN TRYPANOSOMES; NATURAL-POPULATIONS; INDUCED MUTAGENESIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: McKenzie, GJ Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,Room S809 Mail Stop 225, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza,Room S809 Mail Stop 225 Houston TX USA 77030
Citazione:
G.J. McKenzie e S.M. Rosenberg, "Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens", CURR OPIN M, 4(5), 2001, pp. 586-594

Abstract

'Adaptive' or 'stationary-phase' mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:34:45