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Titolo:
New antiretroviral agents: looking beyond protease and reverse transcriptase
Autore:
Miller, MD; Hazuda, DJ;
Indirizzi:
Merck Res Labs, Dept Biol Chem, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486 Dept Biol Chem, W Point, PA 19486 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 5, volume: 4, anno: 2001,
pagine: 535 - 539
SICI:
1369-5274(200110)4:5<535:NAALBP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RECOMBINANT SOLUBLE CD4; CHEMOKINE RECEPTOR CXCR4; SMALL-MOLECULE INHIBITOR; AIDS-RELATED COMPLEX; HIGHLY POTENT; INTEGRASE INHIBITORS; HIV-1 REPLICATION; PEPTIDE INHIBITOR; STRAND TRANSFER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, MD Merck Res Labs, Dept Biol Chem, W Point, PA 19486 USA Merck ResLabs W Point PA USA 19486 hem, W Point, PA 19486 USA
Citazione:
M.D. Miller e D.J. Hazuda, "New antiretroviral agents: looking beyond protease and reverse transcriptase", CURR OPIN M, 4(5), 2001, pp. 535-539

Abstract

The clinical utility of intervention in HIV-1 disease has been proven by inhibitors targeting reverse transcriptase and protease. However, novel approaches including inhibition of viral entry, integration and assembly would provide additional options to maintain long-term suppression. The identification of specific inhibitors for each of these processes has recently validated these approaches as viable alternatives for the development of new agents to treat HIV-1 infection. The most recent preclinical advances in novelantiretroviral agents are reviewed and promising new approaches that target viral processes are highlighted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:28:20