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Titolo:
Dendritic cells in autoimmune diseases
Autore:
Ludewig, B; Junt, T; Hengartner, H; Zinkernagel, RM;
Indirizzi:
Univ Zurich, Inst Expt Immunol, Dept Pathol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 thol, CH-8091 Zurich, Switzerland
Titolo Testata:
CURRENT OPINION IN IMMUNOLOGY
fascicolo: 6, volume: 13, anno: 2001,
pagine: 657 - 662
SICI:
0952-7915(200112)13:6<657:DCIAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; MHC CLASS-I; MOLECULAR MIMICRY; T-CELLS; LYMPHOID NEOGENESIS; TRANSGENIC MICE; ANTIGEN PRESENTATION; MULTIPLE-SCLEROSIS; CROSS-PRESENTATION; LOCAL EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Ludewig, B Univ Zurich, Inst Expt Immunol, Dept Pathol, Schmelzbergstr 12,CH-8091 Zurich, Switzerland Univ Zurich Schmelzbergstr 12 Zurich Switzerland CH-8091 rland
Citazione:
B. Ludewig et al., "Dendritic cells in autoimmune diseases", CURR OP IM, 13(6), 2001, pp. 657-662

Abstract

Subclinical autoimmune responses can be frequently detected in healthy individuals. Sustained activation of autoreactive lymphocytes is, however, required for the development of autoimmune diseases associated with ongoing tissue destruction either in single organs or generalized with multiple manifestations. Clinical and experimental evidence suggests that prolonged presentation of self antigens by dendritic cells is crucial for the development of destructive autoimmune disease. We discuss here a simplified threshold model where the key parameters for the magnitude of the autoimmune response are the amount of previously ignored self peptides presented by dendritic cells and the duration of the antigen presentation in secondary lymphoid organs. Multiple factors influence the threshold for the conversion of an autoimmune response to overt autoimmune disease. Frequent or persistent viral infections of the target organ may favor autoimmune disease by increasing the amounts of released self antigens, generating cytokine-mediated bystanderactivation of self-reactive lymphocytes and/or sustaining a chronic response via neoformation of lymphoid structures in the target organ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:46:17