Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The cytoskeleton and cell volume regulation
Autore:
Pedersen, SF; Hoffmann, EK; Mills, JW;
Indirizzi:
August Krogh Inst, Dept Biochem, DK-2100 Copenhagen, Denmark August Krogh Inst Copenhagen Denmark DK-2100 DK-2100 Copenhagen, Denmark Paul Smiths Coll, New York, NY 12970 USA Paul Smiths Coll New York NY USA12970 miths Coll, New York, NY 12970 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 3, volume: 130, anno: 2001,
pagine: 385 - 399
SICI:
1095-6433(200110)130:3<385:TCACVR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCITES TUMOR-CELLS; ACTIVATED PROTEIN-KINASE; LIGHT-CHAIN KINASE; F-ACTIN CYTOSKELETON; NA+-H+ EXCHANGE; ENDOTHELIAL-CELLS; EPITHELIAL-CELLS; OSMOTIC-STRESS; GROWTH-FACTOR; TYROSINE PHOSPHORYLATION;
Keywords:
F-actin; RVD; RVI; cytochalasins; signal transduction; protein kinases; NHE isoforms; NKCC1; Cl- and K+ channels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, SF August Krogh Inst, Dept Biochem, 13 Univ Pk, DK-2100 Copenhagen, Denmark August Krogh Inst 13 Univ Pk Copenhagen Denmark DK-2100 mark
Citazione:
S.F. Pedersen et al., "The cytoskeleton and cell volume regulation", COMP BIOC A, 130(3), 2001, pp. 385-399

Abstract

Although the precise mechanisms have yet to be elucidated, early events inosmotic signal transduction may involve the clustering of cell surface receptors, initiating downstream signaling events such as assembly of focal adhesion complexes, and activation of, e.g. Rho family GTPases, phospholipases, lipid kinases, and tyrosine- and scrine/threonine protein kinases. In the present paper, we briefly review recent evidence regarding the possible relation between such signaling events, the F-actin cytoskeleton, and volume-regulatory membrane transporters, focusing primarily on our own work in Ehrlich ascites turner cells (EATC). In EATC, cell shrinkage is associated with an increase, and cell swelling with a decrease in F-actin content, respectively. The role of the F-actin cytoskeleton in cell volume regulation in various cell types has largely been investigated using cytochalasins to disrupt F-actin and highly varying effects have been reported. Findings in EATC show that the effect of cytochalasin treatment cannot always be assumed to be F-actin depolymerization, and that, moreover, there is no well-definedcorrelation between effects of cytochalasins on F-actin content and their effects on F-actin organization and cell morphology. At a concentration verified to depolymerize F-actin, cytochalasin B (CB), but not cytochalasin D (CD), inhibited the regulatory volume decrease (RVD) and regulatory volume increase (RVI) processes in EATC. This suggests that the effect of CB is related to an effect other than F-actin depolymerization, possibly its F-actin severing activity. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:28:12