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Titolo:
Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a rheumatologist's perspective
Autore:
Day, RO;
Indirizzi:
St Vincents Hosp, Dept Clin Pharmacol, Sydney, NSW 2010, Australia St Vincents Hosp Sydney NSW Australia 2010 l, Sydney, NSW 2010, Australia Univ New S Wales, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia ew S Wales, Sydney, NSW, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
fascicolo: 6, volume: 19, anno: 2001, supplemento:, 25
pagine: S59 - S62
SICI:
0392-856X(200111/12)19:6<S59:PAPAOT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; STEREOSELECTIVE DISPOSITION; GASTROINTESTINAL TOXICITY; IBUPROFEN ENANTIOMERS; NAPROXEN; PLASMA; OSTEOARTHRITIS; BLISTER;
Keywords:
NSAIDs; rofecoxib; celecoxib; pharmacokinetics; pharmacodynamics; half-life; synovial fluid; clearance; absorption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Day, RO St Vincents Hosp, Dept Clin Pharmacol, Victoria St, Sydney, NSW 2010, Australia St Vincents Hosp Victoria St Sydney NSW Australia 2010 , Australia
Citazione:
R.O. Day, "Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a rheumatologist's perspective", CLIN EXP RH, 19(6), 2001, pp. S59-S62

Abstract

The ideal cyclooxygenase-2-specific inhibitor (coxib) would demonstrate efficacy comparable or superior to the best non-steroidal anti-inflammatory drug (NSAID) and, in addition to being substantially less gastrotoxic than the safest conventional NSAID, would have limited or no cardiovascular or renal toxicity and be generally tolerated as well as placebo. The contribution of the pharmacokinetic properties of a coxib to achieving this goal has been overlooked to some degree for available coxibs. Maximizing synovial compartment exposure while minimizing systemic exposure may deliver tolerability benefits, particularly with respect to rates of hypertension and cardiovascular and thrombotic adverse effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 20:39:21