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Titolo:
Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis
Autore:
Yi, JM; Kim, MS; Seo, SW; Lee, KN; Yook, CS; Kim, HM;
Indirizzi:
Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea Kyung Hee Univ Seoul South Korea 130701 Pharm, Seoul 130701, South Korea
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 312, anno: 2001,
pagine: 163 - 168
SICI:
0009-8981(200110)312:1-2<163:ASRIMC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HISTAMINE-RELEASE; ACTIVATION; COMPOUND-48/80; RATS; SKIN;
Keywords:
Acanthopanax senticosus; anaphylaxis; mast cells; histamine; TNF-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 onbuk, South Korea
Citazione:
J.M. Yi et al., "Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis", CLIN CHIM A, 312(1-2), 2001, pp. 163-168

Abstract

Background: Mast cells synthesize and secrete chemical mediators which play a central role in anaphylaxis. Methods: The effect of Acanthopanax senticosus root (ASR) on mast cell-dependent anaphylaxis was investigated. Results: ASR inhibited compound 48/80-induced systemic anaphylactic shock at the dose of 1.0 g/kg by 50%. When ASR was given as pre-treatment at concentrations ranging from 0.01 to 2.0 g/l, the histamine release from rat peritonealmast cells induced by compound 48/80 was reduced in a dose-dependent manner. ASR (2.0 g/kg) also inhibited passive cutaneous anaphylaxis activated byanti-dinitrophenyl (DNP) IgE to 53.17 +/-6.62%. Moreover, ASR inhibited turner necrosis factor-alpha production in a concentration-dependent manner, and the treatment of 1 g/l blocked the production by 32.5 +/-3.50% comparedto saline value. Conclusions: ASR may possess effective anti-anaphylactic activity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:56:52