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Titolo:
Reference intervals for serum apolipoproteins A-I, A-II, B, C-II, C-III, and E in healthy Japanese determined with a commercial immunoturbidimetric assay and effects of sex, age, smoking, drinking, and Lp(a) level
Autore:
Sakurabayashi, I; Saito, Y; Kita, T; Matsuzawa, Y; Goto, Y;
Indirizzi:
Jichi Med Sch, Omiya Med Ctr, Dept Clin Pathol, Omiya, Saitama 3308503, Japan Jichi Med Sch Omiya Saitama Japan 3308503 , Omiya, Saitama 3308503, Japan Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 280, Japan Chiba Univ Chiba Japan 280 ch Med, Dept Internal Med 2, Chiba 280, Japan Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto, Japan Kyoto Univ Kyoto Japan ch Med, Dept Geriatr Med, Sakyo Ku, Kyoto, Japan Osaka Univ, Sch Med, Dept Internal Med & Mol Sci, Osaka, Japan Osaka UnivOsaka Japan h Med, Dept Internal Med & Mol Sci, Osaka, Japan Tokai Univ, Sch Med, Dept Internal Med, Isehara, Kanagawa 25911, Japan Tokai Univ Isehara Kanagawa Japan 25911 d, Isehara, Kanagawa 25911, Japan
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 312, anno: 2001,
pagine: 87 - 95
SICI:
0009-8981(200110)312:1-2<87:RIFSAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; CHEMISTRY STANDARDIZATION PROJECT; SINGLE RADIAL IMMUNODIFFUSION; INTERNATIONAL-FEDERATION; ENZYME-IMMUNOASSAY; REFERENCE VALUES; PLASMA; QUANTITATION; LIPOPROTEIN(A); ALCOHOL;
Keywords:
apolipoproteins; reference interval; Lp(a); immunoturbidimetric assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sakurabayashi, I Jichi Med Sch, Omiya Med Ctr, Dept Clin Pathol, 1-847 Amanuma Cho, Omiya, Saitama 3308503, Japan Jichi Med Sch 1-847 Amanuma Cho Omiya Saitama Japan 3308503
Citazione:
I. Sakurabayashi et al., "Reference intervals for serum apolipoproteins A-I, A-II, B, C-II, C-III, and E in healthy Japanese determined with a commercial immunoturbidimetric assay and effects of sex, age, smoking, drinking, and Lp(a) level", CLIN CHIM A, 312(1-2), 2001, pp. 87-95

Abstract

Background: Apolipoproteins, which are contained in lipoprotein particles,play important roles in the transport of lipids. Methods: Serum levels of apolipoproteins (apo) A-I, A-II, B, C-II, C-III, and E were determined by immunoturbidimetry in a healthy Japanese study population (1018 men and 1167women, age 20-69 years) to establish reference intervals. Results: Among the 2185 subjects examined, the mean serum value for apoA-I was 1.42 +/- 0.20 g/l, for apoA-II was 0.30 +/- 0.05 g/l, for apoB was 0.87 +/- 0.18 g/l, for apoC-II was 29 +/- 13 mg/l, for apoC-III was 75 +/- 20 mg/l, and for apoE was 36 +/- 9 mg/l A sex difference was detected in the mean serum concentrations of all six apolipoproteins. Alcohol consumption and cigarette use had a slight effect on serum apolipoprotein concentrations. Age effects wereobserved among women in apoB, apoC-II, and apoC-III concentrations. Moreover, individuals with elevated serum lipoprotein (a) [Lp(a), > 300 mg/l] also displayed increased serum apoB and apoC-II levels and an increased apoB/apoA-I ratio. Conclusion: The reference intervals fur apolipoproteins in Japanese adults that we established, using commercially available reagents forautomated analyzers, will be helpful for assessing risk of coronary heart disease and pathological conditions of patients with hyperlipidemia. We recommend use of these reference intervals for the clinical interpretation of serum apolipoprotein concentrations. (C) 2001 Published by Elsevier ScienceB.V.

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Documento generato il 29/03/20 alle ore 08:29:24