Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Electrophysiological effects of ibutilide in patients with accessory pathways
Autore:
Glatter, KA; Dorostkar, PC; Yang, YF; Lee, RJ; Van Hare, GF; Keung, E; Modin, G; Scheinman, MM;
Indirizzi:
Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sect Adult & Pediat Cardiac Electrophysiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA San Francisco Vet Adm Med Ctr, San Francisco, CA USA San Francisco Vet AdmMed Ctr San Francisco CA USA San Francisco, CA USA
Titolo Testata:
CIRCULATION
fascicolo: 16, volume: 104, anno: 2001,
pagine: 1933 - 1939
SICI:
0009-7322(20011016)104:16<1933:EEOIIP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSON-WHITE-SYNDROME; ATRIAL-FIBRILLATION; INTRAVENOUS IBUTILIDE; EFFICACY; FLUTTER; TERMINATION; CONVERSION; SAFETY;
Keywords:
Wolff-Parkinson-White syndrome; fibrillation; antiarrhythmia agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Scheinman, MM Univ Calif San Francisco, Inst Cardiovasc Res, 500 ParnassusAve,MU E 4S Box 1354, San Francisco, CA 94143 USA Univ Calif San Francisco500 Parnassus Ave,MU E 4S Box 1354 San Francisco CA USA 94143
Citazione:
K.A. Glatter et al., "Electrophysiological effects of ibutilide in patients with accessory pathways", CIRCULATION, 104(16), 2001, pp. 1933-1939

Abstract

Background-Atrial fibrillation (AF) may cause life-threatening ventriculararrhythmias in patients with Wolff-Parkinson-White syndrome. We prospectively evaluated the effects of ibutilide on the conduction system in patientswith accessory pathways (AP). Methods and Results-In part I, we gave ibutilide to 22 patients (18 men, 31 +/-3 years of age) who had AF during electrophysiology study, including 6pediatric patients less than or equal to 18 years of age. Ibutilide terminated AF in 21 of 22 patients (95%) during or 8 +/-5 minutes after infusion and prolonged the shortest preexcited R-R interval during AF. Successful ablation was performed in all patients. In part II, ibutilide was given to 18patients ( 14 men, 28 +/- 21 years) to assess its effects on the AP and conduction system. Ibutilide prolonged the antegrade atrioventricular node effective refractory period (ERP) (from 252 +/- 60 to 303 +/- 70 ms; P <0.02). Ibutilide caused transient loss of the delta wave in 1 patient and abolished inducible tachycardia in 2 patients, although retrograde mapping still allowed for successful AP ablation. The antegrade AP ERP prolonged from 275+/- 40 to 320 +/- 60 ms (P <0.01), as did the antegrade AP block cycle length; the retrograde AP ERP and block cycle length similarly prolonged with ibutilide. The relative and effective refractory period of the His-Purkinjesystem increased in 61% of patients after ibutilide. There were no adverseside effects. Conclusions-We report the use of ibutilide in terminating AP-mediated AF, including the first report in the pediatric population. Ibutilide prolongedrefractoriness of the atrioventricular node, His-Purkinje system, and AP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:53:07