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Titolo:
Selective serotonin reuptake inhibitors and myocardial infarction
Autore:
Sauer, WH; Berlin, JA; Kimmel, SE;
Indirizzi:
Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Biostat, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Epidemiol, Philadelphia, PA 19104 USA Hosp Univ Penn, Dept Med, Div Cardiovasc, Philadelphia, PA 19104 USA Hosp Univ Penn Philadelphia PA USA 19104 vasc, Philadelphia, PA 19104 USA
Titolo Testata:
CIRCULATION
fascicolo: 16, volume: 104, anno: 2001,
pagine: 1894 - 1898
SICI:
0009-7322(20011016)104:16<1894:SSRIAM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-HEART-DISEASE; DEPRESSED-PATIENTS; PLATELET SEROTONIN; OPEN-LABEL; SERTRALINE; PAROXETINE; RISK; ASSOCIATION; FLUOXETINE; MEDICATION;
Keywords:
serotonin uptake inhibitors; depression; epidemiology; myocardial infarction; drugs; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kimmel, SE Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, 717 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA Univ Penn 717 Blockley Hall,423 Guardian Dr Philadelphia PA USA 19104
Citazione:
W.H. Sauer et al., "Selective serotonin reuptake inhibitors and myocardial infarction", CIRCULATION, 104(16), 2001, pp. 1894-1898

Abstract

Background-Depress ion is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. Methods and Results-A case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-county area duringa 28-month period. Cases were patients hospitalized with a first MI. Approximately 4 community control subjects per case were randomly selected from the same geographic area using random digit dialing. Detailed information regarding use of antidepressant medication as well as other clinical and demographic data were obtained by telephone interview. A total of 653 cases offirst MI and 2990 control subjects participated. After adjustment, using multivariable logistic regression, for age, sex, race, education, exercise, quantity smoked per day, body mass index, aspirin use, family history of MI, number of physician encounters, and history of coronary disease, diabetes, hypertension, or hypercholesterolemia, the odds ratio for MI among current SSRI users compared with nonusers was 0.35 (95% CI 0.18, 0.68; P <0.01). Non-SSRI antidepressant users had a nonsignificant reduction in MI risk with wide confidence intervals (adjusted odds ratio 0.48, Cl 0.17, 1.32; P=0.15). However, analysis of this group was limited by the small number of exposed subjects. Conclusions-The use of SSRIs may confer a protective effect against MI. This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression.

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Documento generato il 28/01/20 alle ore 20:54:11